analysis	comparison	cell_type	direction	group1	group2	method	source	rank_metric	term_id	term_name	p_value	adjusted_p_value	enrichment_score	normalized_enrichment_score	pathway_size	effect_direction	leading_edge
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ADIPOGENESIS	HALLMARK_ADIPOGENESIS	0.566077003121748	0.984547461368653	-0.398563669519956	-0.965792406497961	119	up_in_group2	ATP5PO,DDT,SQOR,GPX4,TALDO1,GADD45A,ALDH2,SLC25A1,APOE,MGLL,TKT,TANK,JAGN1,SOD1,CMPK1,UBC
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ALLOGRAFT_REJECTION	HALLMARK_ALLOGRAFT_REJECTION	0.187042842215256	0.748171368861024	-0.502436220638328	-1.21434775865044	110	up_in_group2	RPS19,RPL39,RPS3A,RPS9,RPL9,B2M,CDKN2A,CCL22,CD74,LY75,HLA-DRA,IL15,CCL19,HLA-DQA1,IFNGR2,HLA-A
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ANDROGEN_RESPONSE	HALLMARK_ANDROGEN_RESPONSE	0.712669683257919	0.984547461368653	-0.362451276125091	-0.825021524950914	61	up_in_group2	RPS6KA3,B2M,HMGCS1,HMGCR,SAT1,IDI1,ABCC4,PTK2B,DBI
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APICAL_JUNCTION	HALLMARK_APICAL_JUNCTION	0.698675496688742	0.984547461368653	-0.370218688251971	-0.859106138324185	72	up_in_group2	CD99,NECTIN2,FSCN1,ACTB,TJP1,MYL9,MPZL1,MVD,PFN1,ACTG1,TRAF1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APOPTOSIS	HALLMARK_APOPTOSIS	0.902335456475584	0.984547461368653	-0.290681970955453	-0.693708919625802	100	up_in_group2	SQSTM1,BIRC3,ISG20,GPX4,GADD45A,PMAIP1,SAT1,BTG3,CLU,CASP7,SOD2,IER3,CASP3,CDK2,BAX,HMOX1,SOD1,IL18,IL1B
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_BILE_ACID_METABOLISM	HALLMARK_BILE_ACID_METABOLISM	0.798927613941019	0.984547461368653	-0.354606052725731	-0.723145748872841	24	up_in_group2	CYP27A1,GCLM,IDI1,HSD17B4,SOD1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_CHOLESTEROL_HOMEOSTASIS	HALLMARK_CHOLESTEROL_HOMEOSTASIS	0.13080684596577	0.639500135832654	-0.605377517799464	-1.31492293100205	40	up_in_group2	FABP5,SQLE,FDFT1,FDPS,ACAT2,HMGCS1,HMGCR,MVD,ACTG1,SREBF2,IDI1,TMEM97,PNRC1,CLU,S100A11,NFIL3,STARD4,TNFRSF12A,CD9
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_COAGULATION	HALLMARK_COAGULATION	0.00733545989519092	0.0856270822439449	0.47471268174702	1.65459572859805	47	up_in_group1	PDGFB,CFD,LGMN,C2,CAPN2,HTRA1,CRIP2,DUSP6,C1QA,PLAU,PECAM1,FURIN,SERPING1,FYN,LRP1,PLEK,THBD,KLF7,CTSB,SIRT2,SERPINA1,CPQ,TIMP1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_COMPLEMENT	HALLMARK_COMPLEMENT	0.00778428020399499	0.0856270822439449	0.351896124708135	1.40430791020197	111	up_in_group1	MMP12,PDGFB,LGMN,ITGAM,CD36,C2,LIPA,CPM,C1QC,GNG2,DUSP6,C1QA,EHD1,LCP2,JAK2,SERPING1,FCER1G,PLAUR,CTSC,FYN,LRP1,PLEK,PRCP,PIK3CG,GCA,PDP1,CTSB,TIMP2,USP15,SERPINA1,PIK3R5,DOCK4,CPQ,PLSCR1,HSPA5,HSPA1A,ERAP2,TIMP1,DGKH,SH2B3,CD59,WAS,GNB4,DYRK2
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_DNA_REPAIR	HALLMARK_DNA_REPAIR	0.879659211927583	0.984547461368653	-0.296640556539062	-0.705415007061769	94	up_in_group2	GPX4,NME4,DDB2,RALA,TAF10,MPC2,RPA2,POLR2E,EDF1,NME3,COX17,PCNA,SAC3D1,PDE4B,POLR2K,TP53,POLR1D,RBX1,AK3,RAE1,IMPDH2,POLR2A,TAF12,APRT,GTF2A2,ERCC1,SF3A3,POLR2I,TSG101,HPRT1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_E2F_TARGETS	HALLMARK_E2F_TARGETS	0.597077244258873	0.984547461368653	-0.390157031787667	-0.942202609227879	112	up_in_group2	JPT1,CDKN2A,PSIP1,MCM5,UBE2S,LMNB1,RPA2,HMGB3,TMPO,PHF5A,CKS2,MCM7,RAD1,RAN,POLD2,CKS1B,NAP1L1,CDKN1A,BARD1,PCNA,TBRG4,TP53,HMGA1,CTCF,PRDX4,CBX5,HMGB2,TFRC
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	0.0754380399130347	0.474181965167647	0.358966442415231	1.32779697736054	63	up_in_group1	PMP22,INHBA,CXCL12,IGFBP4,VCAN,DAB2,ECM1,HTRA1,ANPEP,PLOD3,TPM1,QSOX1,TGFB1,PMEPA1,FUCA1,PLAUR,TGFBI,LRP1,CD44,COLGALT1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ESTROGEN_RESPONSE_EARLY	HALLMARK_ESTROGEN_RESPONSE_EARLY	0.897058823529412	0.984547461368653	-0.290318207862374	-0.661594447835353	63	up_in_group2	TUBB2B,LAD1,SFN,FDFT1,PMAIP1,NRIP1,SIAH2,FARP1,PPIF,ARL3
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ESTROGEN_RESPONSE_LATE	HALLMARK_ESTROGEN_RESPONSE_LATE	0.757313109425785	0.984547461368653	-0.34816187581937	-0.815529663702885	79	up_in_group2	TSPAN13,PERP,ISG20,FABP5,SFN,FDFT1,EMP2,S100A9,NRIP1,BTG3,SIAH2,FARP1,ALDH3A2,ID2,PPIF,ARL3
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_FATTY_ACID_METABOLISM	HALLMARK_FATTY_ACID_METABOLISM	0.850537634408602	0.984547461368653	-0.309158424110846	-0.728400888197976	85	up_in_group2	ENO3,ACAT2,HMGCS1,IDI1,LGALS1,ALDH3A2,MGLL,CBR3,HSD17B4,ECI1,DLD,LDHA,SMS,CBR1,S100A10,PDHB,PRDX6,ME1,RDH11,G0S2,ACADVL
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_G2M_CHECKPOINT	HALLMARK_G2M_CHECKPOINT	0.662802950474183	0.984547461368653	-0.374011621245934	-0.896991050141164	105	up_in_group2	JPT1,SQLE,HMGN2,MARCKS,MCM5,UBE2S,LMNB1,G3BP1,MT2A,RPA2,DTYMK,HMGB3,BCL3,TMPO,CKS2,NOTCH2,CKS1B,BUB3,BARD1,NUP50,HMGA1,CTCF,KPNB1,ODC1,HSPA8
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_GLYCOLYSIS	HALLMARK_GLYCOLYSIS	0.54978354978355	0.984547461368653	-0.410113470274722	-0.961960422623948	80	up_in_group2	PGAM1,TXN,ISG20,CYB5A,TALDO1,MXI1,CHST2,PPIA,G6PD,KIF2A,IER3,DSC2,GCLC,ARPP19,SOD1,PKM,ENO1,AGRN,POLR3K,DLD,HAX1,GFPT1,LDHA,RBCK1,IL13RA1,TPI1,ME1,CXCR4,AK3
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HEME_METABOLISM	HALLMARK_HEME_METABOLISM	0.963636363636364	0.984547461368653	-0.242583839279913	-0.575531071340137	92	up_in_group2	SLC7A11,MBOAT2,HTATIP2,GCLM,MXI1,BMP2K,GCLC,LPIN2,GLRX5,EIF2AK1,NFE2L1,YPEL5,PRDX2,ISCA1,BPGM,CAT,ARHGEF12,ADIPOR1,NARF,FOXO3,LRP10,DCUN1D1,TFRC,MGST3,PGLS,FBXO7,OPTN,HAGH,GMPS,CIR1,RIOK3,RAD23A,MKRN1,TCEA1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HYPOXIA	HALLMARK_HYPOXIA	0.651757188498403	0.984547461368653	-0.383209249167941	-0.911276456469099	94	up_in_group2	RBPJ,CSRP2,ENO3,ISG20,BTG1,MXI1,CHST2,SLC25A1,PNRC1,SIAH2,MT1E,SLC6A6,IER3,HMOX1,NFIL3,MT2A,ENO1,SDC4,GAPDH,LDHA,ANXA2,CDKN1A,TPI1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_IL2_STAT5_SIGNALING	HALLMARK_IL2_STAT5_SIGNALING	0.0346787182372566	0.254310600406549	0.311224256434215	1.2437509742053	104	up_in_group1	SCN9A,EMP1,NRP1,CISH,ECM1,SLC2A3,FGL2,IL1R2,WLS,PHTF2,MYO1E,P4HA1,SLC39A8,CCND2,BATF3,LRRC8C,FURIN,GALM,CCND3,ADAM19,IFITM3,CD44,PLEC,TNFSF10,IRF8,XBP1,PRNP,NDRG1,BATF,PLSCR1,TIAM1,AHNAK,ANXA4,SLC1A5,TNFRSF4,PNP,P2RX4
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_IL6_JAK_STAT3_SIGNALING	HALLMARK_IL6_JAK_STAT3_SIGNALING	0.607101947308133	0.984547461368653	-0.406604578912247	-0.911578754840866	53	up_in_group2	CSF2RA,CRLF2,EBI3,CXCL3,IFNGR2,HMOX1,IL1B,STAT3,HAX1,TNFRSF12A,CD9,TNFRSF1B,PTPN1,IL13RA1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INFLAMMATORY_RESPONSE	HALLMARK_INFLAMMATORY_RESPONSE	0.81183932346723	0.984547461368653	-0.326879111757743	-0.779476645883553	98	up_in_group2	SELENOS,CCL20,CCR7,CCL22,EBI3,LAMP3,TNFRSF9,IL7R,IL15,CXCL8,CHST2,PTGIR,IFNGR2,CCL17,IL18,IL1B,SRI
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INTERFERON_ALPHA_RESPONSE	HALLMARK_INTERFERON_ALPHA_RESPONSE	0.749718151071026	0.984547461368653	-0.345621753172306	-0.788479265354791	60	up_in_group2	B2M,ISG20,CD74,LAMP3,NUB1,IL15,TRAFD1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INTERFERON_GAMMA_RESPONSE	HALLMARK_INTERFERON_GAMMA_RESPONSE	0.934715025906736	0.984547461368653	-0.271202967577239	-0.659966413179035	128	up_in_group2	IDO1,B2M,ISG20,CD74,HLA-DRB1,IL15,TRAFD1,BTG1,HLA-B,CIITA,HLA-DQA1,HLA-A,CASP7,SOD2,SLAMF7,CASP3,MT2A,SRI,STAT3,LYSMD2,IRF2,TNFAIP2,PTPN1,TRIM26,RBCK1,CD86,CDKN1A,PDE4B,EPSTI1,NFKB1,BPGM,TNFAIP3,ISG15,PELI1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_KRAS_SIGNALING_DN	HALLMARK_KRAS_SIGNALING_DN	0.690658499234303	0.984547461368653	-0.425180665515736	-0.818620786159129	16	up_in_group2	CALML5,SNN,CHST2,KRT5,BARD1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_KRAS_SIGNALING_UP	HALLMARK_KRAS_SIGNALING_UP	0.687768240343348	0.984547461368653	-0.372716656101621	-0.880496305095184	88	up_in_group2	CSF2RA,PRELID3B,CCL20,SLPI,TSPAN13,BIRC3,TFPI,TMEM176A,IL7R,TRAF1,GNG11,TMEM176B,RABGAP1L,ID2
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MITOTIC_SPINDLE	HALLMARK_MITOTIC_SPINDLE	0.978260869565217	0.984547461368653	0.185581229291361	0.740596926138411	111	up_in_group1	RASAL2,DOCK2,MYO1E,VCL,ARHGAP4,MAP1S,ITSN1,BIN1,FGD4,EPB41L2,SUN2,KIF1B,RAPGEF6,PXN,KIF20B,DOCK4,NUSAP1,RASA2,TIAM1,RICTOR,TUBGCP3
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MTORC1_SIGNALING	HALLMARK_MTORC1_SIGNALING	0.792996910401648	0.984547461368653	-0.339004499568549	-0.825077834378831	142	up_in_group2	ATP5MC1,SQSTM1,SLC7A11,SQLE,TXNRD1,HMGCS1,HMGCR,IDI1,TMEM97,PPIA,G6PD,SLC6A6,PPA1,GCLC,NFIL3,PRDX1,DAPP1,ENO1,NFKBIB,RIT1,CCNG1,STARD4,CD9,M6PR,GAPDH,LDHA,CDKN1A,TPI1,EBP,PSMB5,COPS5,NUPR1,ME1,CXCR4,CACYBP
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYC_TARGETS_V1	HALLMARK_MYC_TARGETS_V1	5.09840224882008e-06	0.000224329698948083	-0.681088194805029	-1.6720105130533	174	up_in_group2	RPL34,RPS2,RPS6,RPS3,RPL14,RPL18,RPL6,RPS10,RPS5,RPL22,RACK1,RPLP0,EIF4A1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYC_TARGETS_V2	HALLMARK_MYC_TARGETS_V2	0.978036175710594	0.984547461368653	-0.214833232544078	-0.446597899353257	29	up_in_group2	TMEM97,MCM5,NPM1,TBRG4,MYC,WDR74,NOP16,HSPE1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYOGENESIS	HALLMARK_MYOGENESIS	0.683428571428571	0.984547461368653	-0.379040523554576	-0.851460578404987	54	up_in_group2	NQO1,ENO3,PDE4DIP,FDPS,ADAM12,CLU,GABARAPL2,CNN3,LSP1,MYL6B,COL6A2,RIT1,SYNGR2,AGRN
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_OXIDATIVE_PHOSPHORYLATION	HALLMARK_OXIDATIVE_PHOSPHORYLATION	2.23681457030194e-05	0.000492099205466428	-0.665600640608771	-1.63091142423589	172	up_in_group2	ATP5F1E,ATP5MG,SLC25A6,ATP5MF,ATP5MC2,ATP5ME,ATP5PF,ATP5F1D,ATP5MC3,ATP5F1B,ATP5PD,ATP5PO,ATP5F1C,ATP5MC1,ATP5F1A,ISCU,GPX4,CYB5A
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_P53_PATHWAY	HALLMARK_P53_PATHWAY	0.0271682340647858	0.239080459770115	-0.579969272481795	-1.40173888186172	110	up_in_group2	RPS12,RPL36,RPL18,RPS27L,RACK1,CDKN2A,PERP,SLC7A11,ISCU,SFN,GADD45A,KRT17,TRAFD1,BTG1,HINT1,SAT1,ZMAT3,DDB2,IER3,BAX,HMOX1,RNF19B,MXD4,MDM2,CCNG1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PEROXISOME	HALLMARK_PEROXISOME	0.894545454545455	0.984547461368653	-0.299328439359539	-0.653093835136002	44	up_in_group2	FDPS,IDI1,SOD2,PABPC1,HSD17B4,PRDX1,SOD1,CAT,RDH11,CNBP,PRDX5,ERCC1,HRAS,FIS1,TSPO,ACAA1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PI3K_AKT_MTOR_SIGNALING	HALLMARK_PI3K_AKT_MTOR_SIGNALING	0.527252502780868	0.984547461368653	-0.430994606932132	-0.994180217963489	67	up_in_group2	RPS6KA3,SQSTM1,SFN,RAC1,PFN1,CFL1,MAPK8,CDK2,DAPP1,NCK1,NFKBIB,RIT1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PROTEIN_SECRETION	HALLMARK_PROTEIN_SECRETION	0.984547461368653	0.984547461368653	-0.215155628819126	-0.499276582406634	72	up_in_group2	RPS6KA3,RAB9A
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	0.12958435207824	0.639500135832654	-0.609471653544949	-1.32521338218338	42	up_in_group2	SELENOS,NQO1,TXN,FTL,GPX4,TXNRD1,GCLM,ATOX1,G6PD,SOD2,LSP1,GCLC,PRDX1,SOD1,ABCC1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_SPERMATOGENESIS	HALLMARK_SPERMATOGENESIS	0.942857142857143	0.984547461368653	0.22592954712993	0.624995129927848	19	up_in_group1	ALOX15,DBF4
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_TGF_BETA_SIGNALING	HALLMARK_TGF_BETA_SIGNALING	0.707920792079208	0.984547461368653	0.259559061656569	0.835287560207094	35	up_in_group1	TGFB1,SKI,PMEPA1,CDH1,FURIN,SLC20A1,RAB31,KLF10,SMURF2,NCOR2
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_TNFA_SIGNALING_VIA_NFKB	HALLMARK_TNFA_SIGNALING_VIA_NFKB	0.619732785200411	0.984547461368653	-0.387347877668872	-0.942809449542754	143	up_in_group2	CCL20,DUSP5,SQSTM1,BIRC3,BCL2A1,TNFRSF9,IL7R,GADD45A,BTG1,SNN,MARCKS,KYNU,TRAF1,SAT1,BTG3,PNRC1,CXCL3,EIF1,IFNGR2,TRIP10,TGIF1,RELB,SOD2,IER3,CD83,ID2,TANK,EGR1,NFIL3,RNF19B,IL18,IL1B,BCL3,REL,SDC4,DNAJB4
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	0.622932745314223	0.984547461368653	-0.396393414525962	-0.921301158808965	73	up_in_group2	RPS14,EIF4A1
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UV_RESPONSE_DN	HALLMARK_UV_RESPONSE_DN	0.16899404079279	0.743573779488277	0.323728980382676	1.17466785121794	55	up_in_group1	PMP22,NRP1,FZD2,DAB2,ATP2B4,RUNX1,SDC2,ZMIZ1,TGFBR2,SIPA1L1,FYN
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UV_RESPONSE_UP	HALLMARK_UV_RESPONSE_UP	0.691224268689057	0.984547461368653	-0.36961901777044	-0.866552327514611	82	up_in_group2	SELENOW,SQSTM1,GLS,BTG1,BTG3,SOD2,PPIF,CASP3,CDK2,HMOX1,DNAJA1,GRINA,ALAS1,STK25,CREG1,ARRB2,HLA-F,BCL2L11
deg_pseudobulk	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_XENOBIOTIC_METABOLISM	HALLMARK_XENOBIOTIC_METABOLISM	0.433369447453955	0.984547461368653	-0.457583931650464	-1.07183840567413	79	up_in_group2	DDT,NQO1,CYP27A1,CYB5A,PTGR1,PGD,ALDH2,KYNU,TMEM97,APOE,SLC6A6,TMEM176B,GCLC,ID2,LPIN2,ARPP19,HMOX1,MT2A
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ADIPOGENESIS	HALLMARK_ADIPOGENESIS	0.469642857142857	0.561280487804878	-0.230504727381855	-0.991386062751401	168	up_in_group2	MYLK,EPHX2,GADD45A,HADH,CDKN2C,PTGER3,DGAT1,CHCHD10,ITGA7,LPL,LTC4S,CCNG2,MCCC1,TOB1,UBC,PLIN2,ABCA1,SLC27A1,AGPAT3,SNCG,FAH,MGLL,PPM1B,ARL4A,PHLDB1,DBT,PFKL,ALDH2,SUCLG1,PRDX3
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ALLOGRAFT_REJECTION	HALLMARK_ALLOGRAFT_REJECTION	0.147609147609148	0.234838709677419	0.314714872849218	1.22618585121692	74	up_in_group1	BCL3,SOCS1,IL4R,CAPG,IL15,JAK2,ABI1,IL16,CCND2,CTSS,IRF7,EIF5A,EGFR,GBP2,CD47,STAT1,ETS1,THY1,HLA-DRA,IFNAR2,HIF1A
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ANDROGEN_RESPONSE	HALLMARK_ANDROGEN_RESPONSE	0.0476190476190476	0.124202058721693	-0.370960909894793	-1.40125409611472	73	up_in_group2	HSD17B14,SGK1,TPD52,TNFAIP8,INPP4B,PMEPA1,HMGCS1,ACTN1,IDI1,CCND1,CDC14B,TSC22D1,B2M,GPD1L
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ANGIOGENESIS	HALLMARK_ANGIOGENESIS	0.0220655718556139	0.0877044062143003	0.549080628152573	1.67059634068984	24	up_in_group1	SERPINA5,POSTN,MSX1,VCAN,VEGFA,CCND2,FSTL1,NRP1,COL5A2
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APICAL_JUNCTION	HALLMARK_APICAL_JUNCTION	0.172866520787746	0.256680591472714	0.281106148117513	1.17212600583588	110	up_in_group1	CLDN11,FBN1,VCAN,SKAP2,ADAM9,THBS3,EPB41L2,CD34,YWHAH,FLNC,CADM3,SIRPA,ADAMTS5,CD276,EGFR,MPZL1,LIMA1,BMP1,SGCE,VWF,VCAM1,STX4,CRAT,TJP1,TGFBI,ADAM15,PIK3CB,CAP1,THY1,GTF2F1
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APICAL_SURFACE	HALLMARK_APICAL_SURFACE	0.0246248269444385	0.0877044062143003	0.580814509019337	1.62907519994859	18	up_in_group1	SRPX,EFNA5,FLOT2,DCBLD2,NCOA6,THY1
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APOPTOSIS	HALLMARK_APOPTOSIS	0.00183258608901191	0.0235987536470772	-0.397081266093899	-1.63351497661067	121	up_in_group2	IER3,SOD2,TNFRSF12A,FDXR,DCN,GADD45B,F2R,ENO2,GADD45A,DDIT3,IRF1,HGF,MADD,PPP2R5B,CCND1,ATF3,SQSTM1,HMGB2,CDC25B,SATB1,CDKN1B,PTK2,BNIP3L,RARA,WEE1,NEDD9,CD14,TIMP1
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_BILE_ACID_METABOLISM	HALLMARK_BILE_ACID_METABOLISM	0.148571428571429	0.234838709677419	-0.339178375216618	-1.22849303501769	58	up_in_group2	FDXR,DIO2,EPHX2,PXMP2,ACSL1,IDI1,ISOC1,ABCA2,ABCA1,ABCD3,RXRA,SLC23A2,DHCR24
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_CHOLESTEROL_HOMEOSTASIS	HALLMARK_CHOLESTEROL_HOMEOSTASIS	0.0209850364447463	0.0877044062143003	-0.447149952208631	-1.5804345514237	52	up_in_group2	TNFRSF12A,TP53INP1,CXCL16,ATF5,ANXA5,LPL,HMGCS1,MVD,IDI1,GNAI1,ATF3,FASN,ABCA2,SEMA3B,S100A11,ACTG1
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_COAGULATION	HALLMARK_COAGULATION	0.0257674486885289	0.0877044062143003	0.381592825806498	1.48163521291198	72	up_in_group1	ITGB3,SERPINE1,DPP4,FBN1,DUSP6,ADAM9,CFH,APOC1,CLU,FYN,LRP1,BMP1,VWF,F10,PLAU,C1R,CPQ,C3,S100A13,GSN,TIMP3,PREP,C1S,THBD,CRIP2,F3,SERPING1
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_COMPLEMENT	HALLMARK_COMPLEMENT	0.00259444232556328	0.0254255347905202	0.374774453703185	1.58114374265006	117	up_in_group1	CDH13,PLA2G4A,SERPINE1,DPP4,DOCK4,DUSP6,ADAM9,CFH,JAK2,APOC1,CLU,PLSCR1,CTSS,IRF7,FYN,LRP1,CP,ERAP2,CASP3,F10,STX4,C1R,CPQ,COL4A2,PIK3CA,C3,S100A13,CASP4,GNG2,CBLB,DOCK10,PREP,C1S,USP15,DOCK9,F3,SERPING1,CTSC,CD55,BRPF3,PRDM4,RNF4,GNAI2,CASP1,RABIF,FN1,AKAP10,LAP3
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_DNA_REPAIR	HALLMARK_DNA_REPAIR	1	1	-0.125289067211081	-0.513356040502314	118	up_in_group2	BCAM,POLL,NME4,VPS37B,TAF1C,POLR2A,GMPR2,RAE1,RRM2B,AAAS,ERCC3,SNAPC4,TAF6,USP11,BRF2,DDB2,POLH
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_E2F_TARGETS	HALLMARK_E2F_TARGETS	0.377737226277372	0.487082212831348	-0.252575864714562	-1.03904790523173	121	up_in_group2	CKS2,STMN1,HMGB3,CDKN2C,MCM7,UBE2S,PAN2,HELLS,HMGB2,RAD51C,CDC25B,POLE,CDKN1B,MCM5,NUP153,TFRC,WDR90,DCK,WEE1,MSH2,SMC4
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	0.0268482876166226	0.0877044062143003	0.312034785769509	1.37753111411799	166	up_in_group1	SFRP4,PCOLCE2,ITGB3,NTM,MEST,SERPINE1,BASP1,DKK1,ABI3BP,POSTN,ITGA5,MSX1,FBN1,VCAN,IGFBP3,COL8A2,VEGFA,ECM1,CAPG,PLOD2,IL15,DAB2,IL32,LRP1,COL6A3,DPYSL3,FSTL1,BMP1,COL4A1,SLIT3,VCAM1,NT5E,FAP,TGFBI,COL4A2
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ESTROGEN_RESPONSE_EARLY	HALLMARK_ESTROGEN_RESPONSE_EARLY	0.142857142857143	0.234838709677419	-0.306224633397671	-1.22940198247677	99	up_in_group2	BCL11B,LRIG1,FHL2,SYNGR1,MAST4,THSD4,BCL2,AKAP1,RAB31,TOB1,FKBP4,CCND1,WFS1,INHBB,FASN,UNC119,TFAP2C,SEMA3B,SLC7A2,MED24,SFN,NAV2,ITPK1,RARA,SH3BP5
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ESTROGEN_RESPONSE_LATE	HALLMARK_ESTROGEN_RESPONSE_LATE	0.226843100189036	0.31758034026465	-0.289619244466461	-1.1551241687279	96	up_in_group2	TNNC1,MDK,SGK1,TSPAN13,PTGER3,DCXR,BCL2,PLXNB1,RAB31,TOB1,FKBP4,CCND1,DLG5,WFS1,ZFP36,ACOX2,TFAP2C,SEMA3B,SFN,ITPK1,PERP
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_FATTY_ACID_METABOLISM	HALLMARK_FATTY_ACID_METABOLISM	0.00833851196308739	0.0583695837416117	-0.366120368997401	-1.49204267064317	116	up_in_group2	G0S2,INMT,ENO2,HADH,GCDH,D2HGDH,S100A10,ODC1,ACSL1,AOC3,LTC4S,HCCS,HMGCS1,IDI1,HSP90AA1,ACOT8,ACSS1,FASN
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_G2M_CHECKPOINT	HALLMARK_G2M_CHECKPOINT	0.214936247723133	0.309761062895103	-0.281124441814487	-1.14566054900632	116	up_in_group2	MT2A,MEIS1,MEIS2,CKS2,STMN1,HMGB3,ATF5,CDKN2C,UBE2S,ODC1,CCND1,CDC25B,AMD1,SLC12A2,POLE,CDKN1B,MCM5,TGFB1,RBM14
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_GLYCOLYSIS	HALLMARK_GLYCOLYSIS	0.498201438848921	0.567717918688305	-0.234171446275808	-0.972218793496427	125	up_in_group2	IER3,DCN,IRS2,STMN1,ENO2,SLC16A3,AGRN,NOL3,CITED2,GPC1,FKBP4,PHKA2,B3GALT6,CHPF,DDIT4,MED24,MXI1,ANKZF1
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HEDGEHOG_SIGNALING	HALLMARK_HEDGEHOG_SIGNALING	0.0506947178455888	0.124202058721693	-0.562475683711036	-1.59480377958789	18	up_in_group2	PTCH1,NRP2,HEY2,CNTFR,ETS2
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HEME_METABOLISM	HALLMARK_HEME_METABOLISM	1	1	0.140114045540452	0.596231619886104	125	up_in_group1	AQP3,NFE2L1,RNF19A,P4HA2,CAST,BACH1,HTATIP2,CLIC2,C3,VEZF1,GDE1,AGPAT4,TCEA1,DAAM1,CAT,BPGM,SEC14L1,USP15,ASNS,GYPC,CDC27,CDR2,ARL2BP,FOXJ2,ATP6V0A1,FBXO7,NNT,CLCN3,NUDT4,MINPP1,OPTN,GAPVD1
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HYPOXIA	HALLMARK_HYPOXIA	0.0642201834862385	0.149847094801223	-0.311927655283062	-1.29321644073891	128	up_in_group2	IER3,MT2A,DCN,ADM,TPD52,IRS2,CSRP2,ENO2,BCL2,DDIT3,PGF,CCNG2,TNFAIP3,CITED2,GPC1,TMEM45A,ATF3,ZFP36,DUSP1,PLIN2,B3GALT6,DDIT4,TGFB3,CDKN1B,CDKN1C,MXI1,MT1E,ANKZF1,MAP3K1,PPP1R15A,BNIP3L
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_IL2_STAT5_SIGNALING	HALLMARK_IL2_STAT5_SIGNALING	0.122486288848263	0.222289931613515	-0.303355249635331	-1.22976609108503	108	up_in_group2	HOPX,COCH,PTCH1,RGS16,GADD45B,LRIG1,HIPK2,PTH1R,BCL2,ODC1,POU2F1,SYNGR2,PRNP,ST3GAL4,PHLDA1,CAPN3,PLIN2,SMPDL3A,CDKN1C,FAH,AHCY,ARL4A,TWSG1,IGF1R,MAFF
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_IL6_JAK_STAT3_SIGNALING	HALLMARK_IL6_JAK_STAT3_SIGNALING	0.0452286955648754	0.124202058721693	0.405032031314328	1.46453946261714	51	up_in_group1	ITGB3,PLA2G2A,SOCS1,IL4R,IL13RA1,SOCS3,ACVRL1,IL10RB,IL1R1,OSMR,IFNAR1,TNFRSF1A,STAT1
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INFLAMMATORY_RESPONSE	HALLMARK_INFLAMMATORY_RESPONSE	0.0358712021081466	0.109855556456199	0.34806205158768	1.39984542300915	84	up_in_group1	ITGB3,CD70,SERPINE1,ITGA5,HAS2,IL4R,PTPRE,CMKLR1,IL15,ABI1,NMI,IRF7,KIF1B,IL1R1,OSMR,AHR,EIF2AK2,LPAR1,IFNAR1,PCDH7,SLC31A1,PDPN,DCBLD2,SGMS2,HIF1A
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INTERFERON_ALPHA_RESPONSE	HALLMARK_INTERFERON_ALPHA_RESPONSE	0.0010261367261255	0.0235987536470772	0.439431018060683	1.72372690644348	76	up_in_group1	MX1,PROCR,OAS1,IL4R,ISG20,IL15,PARP9,NMI,NUB1,PLSCR1,NCOA7,IRF7,TRIM21,PARP14,GBP2,TRIM26,CD47,EPSTI1,EIF2AK2,TRIM25,PNPT1,TXNIP,C1S,IFI35,CASP8,IFI44L,PSME1,CASP1,ISG15,PSMB8,IFITM1,LAP3
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INTERFERON_GAMMA_RESPONSE	HALLMARK_INTERFERON_GAMMA_RESPONSE	0.00320550265890572	0.0261782717143967	0.35044560505627	1.51053951742444	138	up_in_group1	PLA2G4A,MX1,MX2,PFKP,FGL2,SOCS1,MVP,IL4R,ISG20,SAMHD1,CMKLR1,IL15,CFH,JAK2,NMI,SOCS3,PLSCR1,IRF7,LATS2,TRIM21,PARP14,TRIM26,EPSTI1,VCAM1,CASP3,C1R,NOD1,EIF2AK2,TRIM25,STAT1,CASP4,TNFAIP2,LYSMD2,IFNAR2,PNPT1,HIF1A,TXNIP,XAF1,RNF213,AUTS2,C1S,BPGM,IFI35,RIPK1,STAT3,CASP8,SERPING1
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_KRAS_SIGNALING_DN	HALLMARK_KRAS_SIGNALING_DN	0.0148477457583701	0.0808377269066819	-0.492021670994091	-1.63378241118535	34	up_in_group2	PAX3,SGK1,KRT5,IGFBP2,THNSL2,CNTFR,GAMT,SYNPO,EFHD1,SHOX2,PDK2
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_KRAS_SIGNALING_UP	HALLMARK_KRAS_SIGNALING_UP	0.0849056603773585	0.166415094339623	-0.323862344423835	-1.29235238848905	97	up_in_group2	G0S2,PCSK1N,INHBA,TSPAN13,PRDM1,RGS16,GADD45G,MAFB,TRIB2,PEG3,SPON1,JUP,TNFAIP3
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MITOTIC_SPINDLE	HALLMARK_MITOTIC_SPINDLE	0.0921348314606742	0.173638720829732	0.282295934350873	1.22241615439528	145	up_in_group1	DOCK4,DYNLL2,TRIO,CDC42EP2,EPB41L2,ABI1,SPTBN1,KIF1B,CLIP1,PKD2,KIFAP3,NIN,SAC3D1,BIN1,ARF6,KIF3B,ABL1,GSN,ABR,SPTAN1,ARHGEF11,FLNB,ARHGEF3,SMC1A,CKAP5,TUBGCP2,PDLIM5,YWHAE,VCL,CDC42,CTTN,ARHGDIA,KIF5B,MAPRE1,CCDC88A,DYNC1H1,FARP1,CDC27,MYO9B,PPP4R2,PXN,RFC1,CDC42EP4
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MTORC1_SIGNALING	HALLMARK_MTORC1_SIGNALING	0.0733333333333333	0.156231884057971	0.284598570026076	1.24006444437967	147	up_in_group1	TES,FGL2,PNO1,SKAP2,NFIL3,PLOD2,RPN1,SQLE,SLC1A5,PITPNB,PSMD12,SDF2L1,PDAP1,CYP51A1,ABCF2,GLRX,HPRT1,TOMM40,PPA1,G6PD,BHLHE40,SLC2A3,TCEA1,PSMC6,EIF2S2,ACSL3,PSMA4,M6PR,EEF1E1,ASNS,ADD3,GBE1,CTSC,LDHA,PSMD14,CCT6A,YKT6,IMMT,PSME3,NMT1,CALR,XBP1,COPS5,HSP90B1,ENO1,IGFBP5,PSMC4,ARPC5L,UFM1,HSPA5,SHMT2
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYC_TARGETS_V1	HALLMARK_MYC_TARGETS_V1	0.986078886310905	1	0.168259784572609	0.743822948615822	171	up_in_group1	KPNA2,NCBP1,GNL3,PA2G4,HPRT1,SYNCRIP,PWP1,DHX15,DEK,CCT5,PSMC6,EIF2S2,HNRNPA3,PSMA4,G3BP1,SRPK1,PSMD7,YWHAE,LDHA,PSMD14,APEX1,SNRPD1,EIF3J,NOP16,RAD23B,CCT2,SNRPG,COPS5,GSPT1,POLE3,HNRNPD,PSMC4,NME1,HDAC2,CBX3,KPNB1,MCM4,VDAC1,NCBP2,HNRNPU,UBE2L3,RANBP1,EIF2S1,NOP56,ERH,VBP1,PRPS2,RNPS1,PGK1,CUL1,HNRNPC,FAM120A,C1QBP,CCT7,NHP2,PSMB2,EIF4H,PSMB3,GLO1,XRCC6,DDX21,TARDBP,YWHAQ,COX5A,PSMD1,SRM,PSMA7,AIMP2,TRA2B,PPM1G,HNRNPR,LSM7,AP3S1,DDX18,FBL,HNRNPA1
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYC_TARGETS_V2	HALLMARK_MYC_TARGETS_V2	0.283673469387755	0.386111111111111	0.315251797950083	1.11948574955428	47	up_in_group1	WDR43,DCTPP1,GNL3,IMP4,PA2G4,MAP3K6,GRWD1,MRTO4,UTP20,NOP16,RABEPK,NIP7,NOP2,CBX3,PRMT3,MYBBP1A,MCM4,PPRC1,NOP56,TBRG4,LAS1L,SRM,AIMP2,IPO4,NOC4L,FARSA,DDX18
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYOGENESIS	HALLMARK_MYOGENESIS	0.0119288554090756	0.0730642393805883	-0.373022687670694	-1.50994334434652	107	up_in_group2	TNNC1,SGCA,GADD45B,MYLK,PTP4A3,KLF5,PLXNB2,CRYAB,CFD,AGRN,MYH11,DMPK,TPM2,ITGA7,ACSL1,MAPRE3,WWTR1,COL1A1,SMTN,SYNGR2,TAGLN,PRNP,FGF2,MEF2C,TSC2,IGF1,NAV2,TGFB1
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_NOTCH_SIGNALING	HALLMARK_NOTCH_SIGNALING	0.0488624851166355	0.124202058721693	-0.516717669659661	-1.54064557593055	22	up_in_group2	DLL1,WNT5A,KAT2A,NOTCH3,FZD1,CCND1
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_OXIDATIVE_PHOSPHORYLATION	HALLMARK_OXIDATIVE_PHOSPHORYLATION	0.908045977011494	0.988761174968071	0.186988873583793	0.829095968192547	179	up_in_group1	PDK4,IDH3A,CPT1A,MRPS22,COX17,ACAA2,ABCB7,CYB5R3,GLUD1,MRPS30,HADHA,NDUFB1,NDUFA3,NDUFS1,NDUFC2,POR,TIMM8B,ACAT1,ETFA,AFG3L2,TIMM13,MRPL11,SDHA,TIMM10,ALAS1,LDHA,UQCRQ,IMMT,NDUFB7,AIFM1,GPX4,RETSAT,UQCR11,TIMM9
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_P53_PATHWAY	HALLMARK_P53_PATHWAY	0.00192642886914916	0.0235987536470772	-0.386138976451156	-1.61950273204022	134	up_in_group2	IER3,KRT17,FDXR,EPHA2,RGS16,PLXNB2,F2R,RRAD,GADD45A,ZMAT3,MKNK2,PIDD1,SLC3A2,PLK2,DCXR,DDIT3,S100A10,CEBPA,TOB1,ATF3,TSPYL2,NINJ1,INHBB,TSC22D1,RAD51C,DDIT4,CTSD,SFN,RXRA,IER5,CD82,SLC35D1,TM4SF1,TGFB1,PPP1R15A,PERP,PDGFA,WRAP73,IP6K2,ANKRA2,FUCA1,PTPN14,JUN
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PEROXISOME	HALLMARK_PEROXISOME	0.15678776290631	0.240081261950287	-0.326006536783401	-1.2221804901815	70	up_in_group2	SOD2,CRABP1,CADM1,EPHX2,SLC25A17,ACSL1,IDI1,ISOC1,ACOT8,ABCD3,SLC23A2,DHCR24,PEX11B,MSH2,ERCC3
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PI3K_AKT_MTOR_SIGNALING	HALLMARK_PI3K_AKT_MTOR_SIGNALING	0.990439770554493	1	-0.168705540537905	-0.634309972246036	72	up_in_group2	MKNK2,PLCG1,DDIT3,PRKAA2,SQSTM1,TSC2,CDKN1B,SFN
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PROTEIN_SECRETION	HALLMARK_PROTEIN_SECRETION	0.8580375782881	0.955541848548112	0.199225367986229	0.804967669064394	87	up_in_group1	AP2B1,PAM,EGFR,KIF1B,COPB1,SEC22B,VPS4B,STX12,SGMS1,ATP7A,M6PR,COG2,SEC24D,RAB5A,CTSC,YKT6,AP1G1,SCRN1,CLTC,STAM,VAMP3,CLCN3,ARFGAP3,LMAN1,SEC31A,BNIP3
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	0.3	0.397297297297297	0.322807283138588	1.10120687263677	39	up_in_group1	MBP,PFKP,SBNO2,LSP1,ABCC1,GLRX,CDKN2D,G6PD,MGST1,PDLIM1
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_SPERMATOGENESIS	HALLMARK_SPERMATOGENESIS	0.429980276134122	0.5267258382643	-0.302423062233525	-1.01969232380004	40	up_in_group2	PCSK1N,HSPA2,TLE4
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_TGF_BETA_SIGNALING	HALLMARK_TGF_BETA_SIGNALING	0.0211846754176675	0.0877044062143003	-0.443212068803863	-1.53896218447452	47	up_in_group2	THBS1,LTBP2,PMEPA1,HIPK2,SMAD1,ID1,ID3,WWTR1,RAB31,TGFBR1,CDKN1C,TGFB1,PPP1R15A,HDAC1
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_TNFA_SIGNALING_VIA_NFKB	HALLMARK_TNFA_SIGNALING_VIA_NFKB	5.72134422458612e-05	0.0028034586700472	-0.438442445679046	-1.82223671044255	129	up_in_group2	G0S2,IER3,CCL2,SOD2,TNFAIP6,INHBA,SGK1,GEM,IRS2,GADD45B,TNFAIP8,DUSP4,PMEPA1,GADD45A,EGR1,CEBPB,PHLDA2,PLK2,ETS2,IER2,KDM6B,IRF1,TNFAIP3,EIF1,ZC3H12A,CCND1,ATF3,SQSTM1,ZFP36,NINJ1,TSC22D1,RCAN1,PHLDA1,DUSP1,ABCA1
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	0.415094339622642	0.521528785679729	0.244191677934476	1.0055194322597	95	up_in_group1	EXOC2,TUBB2A,VEGFA,NABP1,EIF4G1,HYOU1,PARN,NOP14,EIF2AK3,DNAJC3,PDIA5,DCTN1,DDX10,DKC1,KDELR3,LSM1,WIPI1,PAIP1,ASNS,CEBPG,KIF5B,PDIA6,ALDH18A1,EXOSC9,CALR,XBP1,SPCS3,HSP90B1,SRPRB,CNOT6,ATF6,CKS1B,SEC31A,HSPA5
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UV_RESPONSE_DN	HALLMARK_UV_RESPONSE_DN	0.0782997762863535	0.159862043251305	0.302769911581976	1.26734551241074	114	up_in_group1	ITGB3,SERPINE1,TGFBR2,EFEMP1,NFIB,HAS2,GRK5,SFMBT1,DAB2,CDON,ATP2B4,FYN,ABCC1,SDC2,DLC1,SMAD3,CELF2,PRDM2,TJP1,LPAR1,NRP1,COL5A2,BHLHE40,PPARG,TGFBR3,CDK13,MIOS,TFPI,ANXA4,PDLIM5,ADD3,PMP22,F3
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UV_RESPONSE_UP	HALLMARK_UV_RESPONSE_UP	0.133709981167608	0.233992467043315	-0.307286791464464	-1.23079289992914	103	up_in_group2	SOD2,HSPA2,IGFBP2,ENO2,RRAD,DNAJB1,DGAT1,CDC34,IRF1,CDO1,GGH,FKBP4,ATF3,SQSTM1,POLG2,SHOX2,AMD1,CDKN1C,TFRC,RXRB,CREG1,HSPA13,PPAT,NFKBIA,STARD3,NXF1,BTG3,HLA-F,FOS,CYB5R1,BTG2,OLFM1
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_WNT_BETA_CATENIN_SIGNALING	HALLMARK_WNT_BETA_CATENIN_SIGNALING	0.0678294573643411	0.151074700493305	-0.464129788838008	-1.45106296365517	27	up_in_group2	PTCH1,HEY2,NKD1,DLL1,KAT2A,AXIN2,FZD1,GNAI1,DVL2,HDAC11
deg_pseudobulk	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_XENOBIOTIC_METABOLISM	HALLMARK_XENOBIOTIC_METABOLISM	0.482695810564663	0.56314511232544	-0.241195256007492	-0.98293797448466	116	up_in_group2	PTGDS,MT2A,EPHA2,TKFC,ETS2,DCXR,NDRG2,JUP,CDO1,NINJ1,ACOX2,ENPEP,GSS,MCCC2,SLC35D1,IGF1,FAH,AHCY,FBLN1,ALDH2,DHPS,GSTM4,BCAR1,CFB
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ADIPOGENESIS	HALLMARK_ADIPOGENESIS	0.771228771228771	1	-0.391528005800076	-0.910126535636673	177	up_in_group2	DDT,ATP5PO,CAVIN1,HSPB8,GADD45A,ME1,PPP1R15B,PTGER3,RNF11,UBC,GPX3,ACOX1,SOWAHC,POR,MGLL,RIOK3,PFKFB3,ADIPOR2,NABP1,TOB1,DNAJB9,CCNG2,YWHAG,LIPE,PIM3,UBQLN1,DHCR7,CHUK,TANK,COX7B,MCCC1,NKIRAS1,MAP4K3,GRPEL1
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ALLOGRAFT_REJECTION	HALLMARK_ALLOGRAFT_REJECTION	0.0911823647294589	0.309309309309309	-0.537791553062331	-1.23124754214175	88	up_in_group2	RPS19,RPL39,RPL9,RPS3A,RPS9,EREG,HLA-G,HDAC9,TNF,UBE2D1,SOCS1
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ANDROGEN_RESPONSE	HALLMARK_ANDROGEN_RESPONSE	0.0651955867602808	0.244483450351053	-0.554713820810738	-1.26759828076115	84	up_in_group2	RPS6KA3,SELENOP,ALDH1A3,ARID5B,AZGP1,HMGCS1,HPGD,ELL2,SORD,STEAP4,INSIG1,IDI1,ZBTB10,HMGCR,SGK1,DNAJB9,APPBP2,SMS,VAPA,B2M,UBE2J1,SAT1,HOMER2,SRF,NCOA4,GNAI3,PMEPA1,TSC22D1,DHCR24,ELOVL5,PDLIM5,PGM3,PTPN21,PIAS1,SRP19,TMEM50A,MYL12A,MAP7,KRT19,RRP12,GSR,UAP1
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ANGIOGENESIS	HALLMARK_ANGIOGENESIS	0.00858843641677873	0.0772959277510086	0.488665570281407	1.80933088293106	24	up_in_group1	POSTN,COL5A2,COL3A1,CCND2,JAG1,THBD,SLCO2A1,VAV2,VCAN
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APICAL_JUNCTION	HALLMARK_APICAL_JUNCTION	0.374625374625375	0.648390071466995	-0.457607725276357	-1.0578129895649	130	up_in_group2	CDSN,NECTIN4,MAP3K20,NECTIN2,CD99,NECTIN1,IKBKG,CLDN4,WASL,CRB3,GRB7,ADAM9,INSIG1,TJP1,ACTB,ICAM1,ACTG1
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APICAL_SURFACE	HALLMARK_APICAL_SURFACE	0.357984994640943	0.648390071466995	-0.518043454269133	-1.11232044533527	27	up_in_group2	RHCG,CRYBG1,PLAUR
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APOPTOSIS	HALLMARK_APOPTOSIS	0.153846153846154	0.407239819004525	-0.501889403288429	-1.16017519110469	130	up_in_group2	EREG,HMOX1,GADD45A,ISG20,GADD45B,IER3,CDKN1A,CYLD,ATF3,PEA15,PMAIP1,BNIP3L,TNF,SQSTM1,TNFRSF12A,DNAJA1,DDIT3,GPX3,ETF1,GCH1,ANXA1,BMP2,EGR3,RHOB,BCL2L11,SOD2,MCL1,CREBBP,GNA15,SLC20A1,JUN,BCL10,PSEN1,SMAD7,CFLAR,IL18,HSPB1,SAT1,BTG3,IGF2R,BIRC3,ERBB3,CLU,PTK2,CTNNB1,CASP3,IRF1,PPP2R5B
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_BILE_ACID_METABOLISM	HALLMARK_BILE_ACID_METABOLISM	0.925403225806452	1	-0.298862375662143	-0.680136660012392	67	up_in_group2	AQP9,SULT2B1,IDI1,PNPLA8,NPC1,DIO2,LIPE,DHCR24,GCLM,BCAR3,HACL1
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_CHOLESTEROL_HOMEOSTASIS	HALLMARK_CHOLESTEROL_HOMEOSTASIS	0.0524193548387097	0.238261738261738	-0.579682399274561	-1.31804960620524	62	up_in_group2	PLAUR,HMGCS1,ATF3,ERRFI1,NFIL3,CPEB2,TNFRSF12A,IDI1,HMGCR,TM7SF2,ACTG1,FABP5,PNRC1,S100A11,STX5,MAL2,LGMN,LDLR,DHCR7,GNAI1,NSDHL,CHKA,MVK,ATXN2,CLU,TP53INP1,CTNNB1,SREBF2,FASN,CXCL16
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_COAGULATION	HALLMARK_COAGULATION	0.902805611222445	1	-0.321577764159138	-0.73384175194274	78	up_in_group2	CTSV,MAFF,SERPINB2,DUSP14,ARF4,ADAM9,ANXA1,LGMN,FURIN,ITGA2,DCT,F3,WDR1,KLK8,SIRT2,CTSB,COMP,CLU,TF
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_COMPLEMENT	HALLMARK_COMPLEMENT	0.688311688311688	1	-0.404340203948689	-0.934510793295165	129	up_in_group2	CTSV,MAFF,ME1,DUSP5,S100A9,PRSS3,PLAUR,TNFAIP3,SERPINB2,CXCL1,ADAM9,CD55,EHD1,PPP2CB,CDA,RAF1,CD59,PIM1,CEBPB,PRKCD,LGMN,BRPF3,CTSL,GMFB,HSPA1A,PSEN1,F3,DOCK9,GNAI3,CALM1,PRSS36,CTSB,ATOX1,PDP1,CLU,HSPA5,SRC,PPP4C,CASP3,IRF1
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_DNA_REPAIR	HALLMARK_DNA_REPAIR	0.996003996003996	1	-0.246267754549587	-0.570792887358379	140	up_in_group2	ELOA,NPR2,TAF13,VPS37B,STX3,ELL,PNP,GTF2B,CDA,ARL6IP1,GTF2H1,POLR2A,SRSF6,GTF2A2,RAE1,EIF1B,SUPT5H,ALYREF,ERCC1,SUPT4H1,DCTN4,POM121,TSG101,POLB,SEC61A1,GTF3C5,CANT1,POLR1D,ADCY6,ERCC2,GUK1,POLR2K,TAF9,SDCBP,RNMT,POLR2C,TAF10
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	NA	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_E2F_TARGETS	HALLMARK_E2F_TARGETS	NA	NA	0.416208451264361	NA	185	NA	DLGAP5,BUB1B,CIT,MKI67,MYBL2,CDKN3,SPC25,RRM2,AURKB,TOP2A,TK1,CDK1,LMNB1,MXD3,TIMELESS,MCM3,DEPDC1,TACC3,CDCA8,CCNB2,BRCA2,GINS1,E2F8,BIRC5,CDC25B,HELLS,MELK,BARD1,UBE2T,CDCA3,HMMR,KIF2C,PSIP1,TMPO,SMC1A,DNMT1,RFC3,RNASEH2A,CENPE,MCM4,LBR,LIG1,MCM6,POLD1,CENPM,SMC6,DUT,MCM5,CSE1L,POLD3,MAD2L1,KIF22,CDC20,BRMS1L,SSRP1,SPAG5,TP53,ANP32E,PSMC3IP,MSH2,CCP110,RAD50,NCAPD2,CKS1B,CBX5,RFC1,RAD51AP1,AURKA,PA2G4,RANBP1,NAA38,RAD51C,PRKDC,SHMT1,CTPS1,UNG,RACGAP1,DSCC1,CHEK1,NBN,PAICS,RPA1,HMGB3,ASF1A,PCNA,NUP107,TUBG1,MMS22L,NME1,BRCA1,RFC2
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	0.951048951048951	1	-0.319366615089776	-0.740585613700688	142	up_in_group2	FBN2,CXCL8,GADD45A,AREG,PLAUR,GADD45B,QSOX1,TNFAIP3,CXCL1,TNFRSF12A,GEM,ID2,SDC4,BASP1,RHOB,CD59,MSX1,ITGA2,JUN,NOTCH2,MCM7,ECM1,SAT1,SLC6A8,PMEPA1,FSTL3,COMP,COL6A2
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ESTROGEN_RESPONSE_EARLY	HALLMARK_ESTROGEN_RESPONSE_EARLY	0.196803196803197	0.492007992007992	-0.485382650193214	-1.12638112459567	146	up_in_group2	HSPB8,PPIF,SULT2B1,AREG,UGCG,NBL1,KLK10,SLC19A2,ELF3,TTC39A,PMAIP1,WWC1,NRIP1,SEC14L2,ZNF185,SLC7A5,TIPARP,SCNN1A,TFF3,SYBU,KLF10,EGR3,BHLHE40,IL6ST,TOB1,TIAM1,ABLIM1,MREG,RHOD,CLIC3,KLF4,FHL2,GLA,AFF1,DHCR7,SFN,ELF1,BAG1,FOS,GFRA1,ELOVL5,XBP1,MED13L,SIAH2,FASN,SNX24,RAB31,NPY1R,NADSYN1,KRT19,FDFT1,RRP12,BLVRB,ESRP2,RARA,CANT1,ISG20L2,MAST4,BCL2,TMEM164,KDM4B,TGIF2,KRT15
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ESTROGEN_RESPONSE_LATE	HALLMARK_ESTROGEN_RESPONSE_LATE	0.675324675324675	1	-0.40730965924587	-0.945204596533097	146	up_in_group2	HSPB8,PPIF,ISG20,SULT2B1,AREG,S100A9,NBL1,KLK10,GAL,PTGER3,NRIP1,KLK11,ZFP36,SORD,SLC7A5,SCNN1A,TFF3,FABP5,SGK1,ID2,EGR3,IL6ST,TOB1,PERP,TIAM1,CLIC3,DUSP2,KLF4,GLA,AFF1,HOMER2,BTG3,DHCR7,SFN,BAG1,FOS,ELOVL5,XBP1
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_FATTY_ACID_METABOLISM	HALLMARK_FATTY_ACID_METABOLISM	0.836163836163836	1	-0.364311918215672	-0.842293825945818	124	up_in_group2	KMT5A,ME1,TP53INP2,HMGCS1,HPGD,MAOA,GABARAPL1,IDI1,SDHA,HSPH1,ACOX1,MGLL,ADIPOR2,HSP90AA1,G0S2,ODC1,SMS,SERINC1,HCCS,DLST,DHCR24,NSDHL,ACADVL,ELOVL5,ACAA1
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	NA	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_G2M_CHECKPOINT	HALLMARK_G2M_CHECKPOINT	NA	NA	0.280668745892719	NA	179	NA	CCNA2,BUB1,MKI67,MYBL2,E2F1,CDKN3,KIF15,TROAP,PRC1,AURKB,CENPF,TTK,TOP2A,CDK1,LMNB1,KIF11,CDC45,INCENP,NDC80,MCM3,PBK,UBE2C,CENPA,CDC7,TACC3,CCNB2,BRCA2,TPX2,KIF23,BIRC5,CDC25B,BARD1,RBL1,FOXN3,HMMR,KIF2C,TMPO,SMC1A,SMC2,CENPE,KIF20B,LBR,MCM6,WRN,NEK2,MCM5,HOXC10,MAD2L1,KIF22,GINS2,CDC20
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_GLYCOLYSIS	HALLMARK_GLYCOLYSIS	0.969030969030969	1	-0.309655744446563	-0.718470141800344	160	up_in_group2	ISG20,TGFA,ME1,IRS2,PGAM1,IER3,QSOX1,ELF3,HK2,PPP2CB,DSC2,TFF3,CXCR4,HOMER1,CITED2,GCLC,GPR87,RRAGD,ERO1A,ZNF292,ECD,B4GALT4,NSDHL,PSMC4,SOX9,HSPA5,P4HA1,TPST1,MET,GOT1,TALDO1
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HEDGEHOG_SIGNALING	HALLMARK_HEDGEHOG_SIGNALING	0.7734375	1	0.234500771305473	0.782673786647	18	up_in_group1	THY1,LDB1,DPYSL2,NRP1,PML,CELSR1,MYH9
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HEME_METABOLISM	HALLMARK_HEME_METABOLISM	0.48951048951049	0.815850815850816	-0.438267697807298	-1.01718864552506	144	up_in_group2	OSBP2,MAP2K3,KAT2B,TOP1,ELL2,BNIP3L,SMOX,ATP6V0A1,BTRC,MBOAT2,YPEL5,CTNS,FOXO3,RIOK3,CLIC2,LPIN2,BACH1,BMP2K,ADIPOR1,SEC14L1,RANBP10,TSPAN5,LRP10,NEK7,SLC30A1,GCLC,PICALM,MARK3,CCDC28A,CLCN3,SLC11A2,NCOA4,SLC6A8,CTSB,BPGM,RBM5,DAAM1,GCLM,FOXJ2,CAST,NR3C1,MOSPD1,PPP2R5B,SIDT2,KDM7A,ARHGEF12,HTATIP2,LAMP2,SYNJ1,PC,MKRN1,BLVRB,USP15,NUDT4,GDE1,KHNYN,EZH1,KLF3,SDCBP,MFHAS1,TFRC,ATG4A
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HYPOXIA	HALLMARK_HYPOXIA	0.0130775583106524	0.0840700177113371	-0.558199027200013	-1.29528356906968	154	up_in_group2	RBPJ,CAVIN1,HMOX1,MAFF,ISG20,SULT2B1,NEDD4L,IRS2,AMPD3,PLAUR,IER3,CDKN1A,TNFAIP3,PPP1R15A,FOSL2,ATF3,ERRFI1,NFIL3,BNIP3L,ZFP36,KLHL24,ADM,NOCT,HK2,DDIT3,FOXO3,TIPARP,CXCR4,PFKFB3,ETS1,JMJD6,SDC4,PNRC1,RORA,IDS,EFNA1,BHLHE40,CITED2,PIM1,CCNG2,TES,JUN,RRAGD,TMEM45A,ERO1A,KLF6,ZNF292,BTG1,F3
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_IL2_STAT5_SIGNALING	HALLMARK_IL2_STAT5_SIGNALING	0.0529470529470529	0.238261738261738	-0.526181495452793	-1.21677021572524	134	up_in_group2	IL1RL1,MAFF,CD83,MXD1,GADD45B,HOPX,CCNE1,PRKCH,SNX9,PHLDA1,PNP,NFIL3,MAP3K8,SOCS1,POU2F1,GABARAPL1,HK2,TTC39B,MYO1E,IL1R2,BMP2,ETV4,RORA,RHOB,HUWE1,BHLHE40,PIM1,PRNP,TIAM1,IRF6,ODC1,FURIN,MAPKAPK2,PHTF2,RRAGD,KLF6,ECM1,RGS16,COCH,IGF2R,SH3BGRL2,XBP1,PLAGL1,P4HA1,LTB,CDKN1C,P2RX4,CASP3
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_IL6_JAK_STAT3_SIGNALING	HALLMARK_IL6_JAK_STAT3_SIGNALING	0.319796954314721	0.625689693224454	-0.499641423637685	-1.1229403466214	53	up_in_group2	CSF2RA,HMOX1,CXCL3,CXCL1,MAP3K8,TNF,SOCS1,TNFRSF12A,IL1R2,OSMR,PIM1,IL6ST,JUN,CBL,PTPN11
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INFLAMMATORY_RESPONSE	HALLMARK_INFLAMMATORY_RESPONSE	0.031031031031031	0.17454954954955	-0.564623919607285	-1.2952160189764	100	up_in_group2	SELENOS,AQP9,CXCL8,CCL20,EREG,HBEGF,MXD1,PLAUR,SGMS2,CDKN1A,IRAK2,SLC31A2,SLC31A1,NFKBIA,KIF1B,CD55,ADM,NAMPT,GCH1,ICAM1,OSMR,NFKB1,RAF1,PTPRE,GNA15,SPHK1,RIPK2,PSEN1,KLF6,IL18,SLC11A2,F3,EDN1,RGS16,GNAI3,LDLR,ATP2A2,HRH1
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	NA	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INTERFERON_ALPHA_RESPONSE	HALLMARK_INTERFERON_ALPHA_RESPONSE	NA	NA	0.300625547298454	NA	80	NA	PARP9,IFI30,NMI,IFITM1,PARP14,TRIM21,RNF31,IFI44L,IRF9,SP110,IFI35,IFIT3,TRIM14,HERC6,TAP1,PSMB9,UBE2L6,SAMD9L,PROCR,LGALS3BP,MOV10,PSME2,DDX60,CD47,IFITM3,PSMB8,GBP2,STAT2,LPAR6,PLSCR1,CASP1,IFI44,PSME1
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INTERFERON_GAMMA_RESPONSE	HALLMARK_INTERFERON_GAMMA_RESPONSE	0.945054945054945	1	-0.324839366168709	-0.752904090436935	140	up_in_group2	HLA-G,OASL,UPP1,ISG20,CDKN1A,ARID5B,TNFAIP3,PNP,PELI1,LATS2,NFKBIA,SOCS1,ISG15,NAMPT,HLA-DRB1,GCH1,ICAM1,NFKB1,PIM1,SOD2,ST3GAL5,TRIM25,RIPK2,BTG1,IFI27,B2M,CD74,TNFAIP2
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_KRAS_SIGNALING_DN	HALLMARK_KRAS_SIGNALING_DN	0.633802816901408	1	-0.412774637700232	-0.940431505451079	70	up_in_group2	SELENOP,KLK7,CALML5,TGM1,SLC6A14,SERPINB2,SKIL,ALOX12B,SGK1,THRB,CPEB3,EDN1,KLK8,LYPD3
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_KRAS_SIGNALING_UP	HALLMARK_KRAS_SIGNALING_UP	0.0629370629370629	0.244483450351053	-0.5346536899614	-1.23260669750786	114	up_in_group2	PRELID3B,ARG1,CSF2RA,CCL20,EREG,SLPI,ALDH1A3,MALL,PRDM1,HBEGF,PLAUR,TNFAIP3,HDAC9,PPP1R15A,TRIB1,TOR1AIP2,CXCR4,ETS1,BMP2,ID2,ETV4,GFPT2,G0S2,AVL9,GADD45G,ITGA2,ADAM17,YRDC,ERO1A,KLF4,CBL
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	NA	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MITOTIC_SPINDLE	HALLMARK_MITOTIC_SPINDLE	NA	NA	0.249081796062696	NA	179	NA	DLGAP5,BUB1,KIF15,PRC1,CENPF,TTK,TOP2A,CDK1,LMNB1,KIF11,INCENP,NDC80,ANLN,CCNB2,BRCA2,TPX2,KIF23,BIRC5,SASS6,SYNPO,PKD2,SAC3D1,KIF2C,SMC1A,TUBGCP5,CENPE,CDK5RAP2,CNTRL,KIF20B,FGD6,CKAP5,NEK2,KNTC1,ARHGEF3
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MTORC1_SIGNALING	HALLMARK_MTORC1_SIGNALING	0.28971028971029	0.620807763664907	-0.463333933164806	-1.07685882830362	181	up_in_group2	ATP5MC1,DAPP1,ME1,MAP2K3,EDEM1,CDKN1A,HMGCS1,PPP1R15A,PNP,IFRD1,NFIL3,NFKBIB,SQSTM1,TXNRD1,UBE2D3,SORD,RIT1,INSIG1,NAMPT,IDI1,HK2,MTHFD2L,DDIT3,SLC7A5,ETF1,HMGCR,CXCR4,TM7SF2,DDX39A,ADIPOR2,RAB1A,ATP6V1D,BHLHE40,GTF2H1,UFM1,LGMN,GCLC,STIP1,TES,M6PR,ERO1A,SERP1,ARPC5L,HSPA9,GLA,LDLR,DHCR7,ACTR3,ATP2A2,DHCR24,PSMC4,YKT6,ELOVL5,XBP1,TBK1,HSPA5,P4HA1,GOT1,CORO1A,GSK3B
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYC_TARGETS_V1	HALLMARK_MYC_TARGETS_V1	0.00561431853612597	0.0631610835314172	-0.564916875518931	-1.31581241312354	192	up_in_group2	RPS6,RPL34,RPL18,RPS2,RPS3,RPS5,RPL14,RPLP0,RPL6,RPS10,RPL22,RACK1,EIF4A1
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYC_TARGETS_V2	HALLMARK_MYC_TARGETS_V2	0.836312941185749	1	0.205392379370638	0.981584410328999	54	up_in_group1	MAP3K6,IPO4,MCM4,LAS1L,EXOSC5,MCM5,MYBBP1A,PA2G4,UNG,MPHOSPH10,RRP9,PPAN,CBX3,DDX18,PES1,WDR43,DCTPP1,TCOF1,RABEPK
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYOGENESIS	HALLMARK_MYOGENESIS	0.725274725274725	1	-0.395169974960789	-0.910770911308067	113	up_in_group2	HSPB8,KIFC3,HBEGF,GADD45B,CDKN1A,SMTN,GABARAPL2,IFRD1,RIT1,GPX3,LPIN1,CHRNB1,MEF2D,CRYAB,EIF4A2,BHLHE40,PRNP,EPHB3,ABLIM1,TEAD4,SPHK1,NQO1,FLII,SLC6A8,SIRT2,BAG1,COL6A2,ERBB3,CLU,WWTR1,HDAC5,SPTAN1,DMPK,PC,TNNT1,KLF5,ITGA7,ATP6AP1,PDE4DIP,MRAS,CNN3,AEBP1,PICK1,FDPS,ACSL1,AKT2
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_NOTCH_SIGNALING	HALLMARK_NOTCH_SIGNALING	0.898488120950324	1	-0.299826027399711	-0.641869395957693	26	up_in_group2	PPARD,NOTCH2,ST3GAL6,FBXW11,CUL1,SKP1
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_OXIDATIVE_PHOSPHORYLATION	HALLMARK_OXIDATIVE_PHOSPHORYLATION	0.000239240934292754	0.00538292102158697	-0.598430382968633	-1.39396069779845	199	up_in_group2	ATP5F1E,ATP5MG,ATP5MF,ATP5F1B,SLC25A6,ATP5ME,ATP5PF,ATP5MC2,ATP5MC3,ATP5PB,ATP5MC1,ATP5F1D,ATP5PD,ATP5PO,ATP5F1A,ATP5F1C
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_P53_PATHWAY	HALLMARK_P53_PATHWAY	0.0111346297818653	0.0835097233639895	-0.558723216606986	-1.29765650502283	174	up_in_group2	RPS12,RPL18,RPL36,RACK1,RPS27L,HMOX1,TAX1BP3,UPP1,GADD45A,TGFA,HBEGF,RRAD,MXD1,SLC19A2,IER3,KRT17,CDKN1A,PPP1R15A,PPM1D,IER5,ATF3,EPHA2,SOCS1,GM2A,DDIT3,TM4SF1,FOXO3,RCHY1,SLC3A2,AEN,BMP2,HEXIM1,KIF13B,IP6K2,PTPRE,CDKN2B,PLK2,TOB1,PERP,PLK3,SPHK1,JUN,MAPKAPK3,KLF4,BTG1,CSRNP2,RAP2B,RGS16,KLK8,SAT1,TRAF4,SFN,RNF19B,TSC22D1,RALGDS
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PEROXISOME	HALLMARK_PEROXISOME	0.977955911823647	1	-0.242202871062565	-0.552861562381566	79	up_in_group2	SULT2B1,IDI1,ACOX1,SEMA3C,CDK7,SOD2,VPS4B,PABPC1,SIAH1,BCL10,CLN8,DHCR24,ERCC1,ELOVL5,ACAA1,SLC25A17,PEX13
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PI3K_AKT_MTOR_SIGNALING	HALLMARK_PI3K_AKT_MTOR_SIGNALING	0.251755265797392	0.596262471625402	-0.49427762450815	-1.12919513533637	85	up_in_group2	RPS6KA3,GRK2,DAPP1,MAP2K3,CDKN1A,NFKBIB,SQSTM1,MAPK8,UBE2D3,RIT1,AKT1S1,EIF4E,DDIT3,CXCR4,RAF1,ARF1,TIAM1,CAB39,DUSP3,PTPN11,SFN,ACTR3,CLTC,MKNK2,TBK1,GSK3B,ATF1,HSP90B1,MAPK1,CSNK2B,MAP3K7,TRIB3,ACACA,CAB39L,TRAF2,ARPC3
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PROTEIN_SECRETION	HALLMARK_PROTEIN_SECRETION	0.31062124248497	0.625689693224454	-0.476824302969009	-1.09415338643639	94	up_in_group2	RPS6KA3,VAMP7,KIF1B,RAB5A,STAM,ATP6V1H,SEC22B,AP1G1,BNIP3,ARF1,RAB9A,RAB22A,VPS4B,ADAM10,CLTA,GOLGA4,NAPA,M6PR,CLCN3,GLA,GBF1,IGF2R,CLTC,YKT6,GOSR2,YIPF6,GNAS,ARCN1,STX12,RAB14,TSG101,SNX2,LAMP2
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	0.124229979466119	0.34939681724846	-0.57846459816888	-1.27677565472549	42	up_in_group2	SELENOS,FTL,OXSR1,TXNRD1,GPX3,JUNB,SOD2,PRNP,GCLC,ABCC1,NQO1,HMOX2,ATOX1,MGST1,GCLM,TXN,SCAF4,NDUFA6,GSR,SBNO2,MBP,ERCC2,GLRX
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_SPERMATOGENESIS	HALLMARK_SPERMATOGENESIS	1	1	0.218189636011004	1.05972137001279	55	up_in_group1	BUB1,CDKN3,TTK,CDK1,CCNB2,KIF2C,POMC,TOPBP1,NEK2,SPATA6,PSMG1,RAD17
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_TGF_BETA_SIGNALING	HALLMARK_TGF_BETA_SIGNALING	0.0993914807302231	0.309309309309309	-0.573617260365617	-1.28545749953788	50	up_in_group2	PPP1R15A,SKIL,UBE2D3,TJP1,SMURF1,JUNB,PPM1A,BMP2,ID2,KLF10,TRIM33,SMURF2,FURIN,SLC20A1,ARID4B,RHOA,SMAD7,PMEPA1,BCAR3,CDKN1C,CTNNB1,WWTR1,RAB31,ACVR1,TGFBR1,CDH1,MAP3K7
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_TNFA_SIGNALING_VIA_NFKB	HALLMARK_TNFA_SIGNALING_VIA_NFKB	5.42184210595103e-10	2.43982894767796e-08	-0.709197949782772	-1.64462978949105	158	up_in_group2	CCL20,MAFF,FOSL1,GADD45A,CD83,AREG,DUSP5,IRS2,HBEGF,MAP2K3,MXD1,PLAUR,GADD45B,IER3,CDKN1A,TNFAIP3,CXCL3,PHLDA2,SERPINB2,PPP1R15A,IER5,CXCL1,FOSL2,PHLDA1,PER1,ATF3,NFIL3,MAP3K8,RCAN1,TNF,NFKBIA,SQSTM1,EIF1,ZFP36,EGR1,CXCL2,SERPINB8,NAMPT,CCNL1,IER2,GEM,LITAF,EHD1,TRIB1,ZBTB10,NFKBIE,NR4A3,TIPARP,GCH1,ICAM1,PFKFB3,JUNB,SGK1,TNIP1,BMP2,ID2,SDC4,PNRC1,KLF10,EGR3,NFAT5,RELB,NFKB1,GFPT2,RHOB,PTPRE,EFNA1,BHLHE40,G0S2,PLK2,NFKB2,SOD2,MCL1,IL6ST,CEBPB,ZC3H12A,KDM6B,SPHK1,JUN,REL,EGR2,RIPK2,YRDC,KLF6,DUSP2,KLF4,CFLAR,BTG1,IL18,F3,TRIP10,TNFAIP2,EDN1,SAT1,SPSB1,TUBB2A,B4GALT5,DUSP4,BTG3,LDLR,PMEPA1,RNF19B,TSC22D1,NR4A1
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	0.103103103103103	0.309309309309309	-0.526747148035348	-1.21147394107913	104	up_in_group2	RPS14,EIF4A1,MTREX,SRPRA,EDEM1,ERN1,ATF4,ATF3,ATP6V0D1,EIF4E,SLC7A5,DNAJA4,NFYA,BAG3,NABP1,EIF4A2,CNOT2,HERPUD1,EIF4A3,CEBPB,DNAJB9,ERO1A,SERP1,DCP2,ZBTB17,HSPA9,CNOT6,TUBB2A,NPM1,CXXC1,DCP1A,FUS,EIF4G1,XBP1,HSPA5,GOSR2,KIF5B,EIF2AK3,EIF2S1,YWHAZ,EEF2
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UV_RESPONSE_DN	HALLMARK_UV_RESPONSE_DN	0.887112887112887	1	-0.345663101899149	-0.796163592070098	112	up_in_group2	ADGRL2,NR1D2,INSIG1,SYNJ2,TJP1,MGLL,NEK7,YTHDC1,DYRK1A,NFKB1,BHLHE40,CITED2,ABCC1,SYNE1,NOTCH2,NIPBL,RND3,SMAD7,FHL2,F3,SCAF8,LDLR,PRDM2,ANXA2,KALRN,PDLIM5,MET,KIT,PTPN21,NR3C1
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UV_RESPONSE_UP	HALLMARK_UV_RESPONSE_UP	0.00345932430766559	0.0518898646149838	-0.602683295662209	-1.39225794299798	123	up_in_group2	SELENOW,NUP58,HMOX1,PPIF,CTSV,RRAD,GAL,CDC34,CCNE1,ATF3,FGF18,CREG1,NFKBIA,SQSTM1,CXCL2,MAOA,DNAJA1,ATP6V1C1,GPX3,EIF5,NXF1,AGO2,GCH1,ICAM1,JUNB,BMP2,HSPA13,POLG2,RHOB,CLTB,BCL2L11,CDKN2B,SOD2,IL6ST,PRKCD,MSX1,GLS,FURIN,STIP1,TYRO3,TMBIM6,DNAJB1,BTG1,PPP1R2,SLC6A8,BTG3,NR4A1,CHKA,FOS,YKT6,GRPEL1,ACAA1,CDKN1C,FOSB,CASP3,IRF1
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_WNT_BETA_CATENIN_SIGNALING	HALLMARK_WNT_BETA_CATENIN_SIGNALING	0.278775079197466	0.620807763664907	-0.53810320359	-1.16464530823168	30	up_in_group2	CSNK1E,RBPJ,PPARD,NUMB,ADAM17,GNAI1,CUL1,MAML1,CTNNB1,HDAC5,NCSTN,DVL2
deg_pseudobulk	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_XENOBIOTIC_METABOLISM	HALLMARK_XENOBIOTIC_METABOLISM	0.364635364635365	0.648390071466995	-0.459597149544093	-1.06241177301179	130	up_in_group2	ARG1,DDT,AQP9,HMOX1,UPP1,SERTAD1,PPARD,XDH,NDRG2,EPHA2,SMOX,MAOA,GABARAPL1,ACOX1,CDA,GCH1,POR,LPIN2,ID2,PTGR1,NPC1,AKR1C2,PINK1,GCLC,HSD17B2,TMBIM6,NQO1,SAR1B,ATP2A2,SLC46A3,ELOVL5,LCAT,MT2A,PDLIM5,HACL1,TPST1,DHRS7,SLC12A4,PGRMC1,SSR3,TMEM176B,JUP
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ADIPOGENESIS	HALLMARK_ADIPOGENESIS	0.491493383742911	0.633557422969188	-0.245164092117271	-0.991534336654055	93	up_in_group2	PDCD4,GADD45A,STOM,HIBCH,UQCR10,RNF11,UBC,CHCHD10,ECHS1,JAGN1,CMPK1,DNAJB9,GPX4,CCNG2,ACO2,IFNGR1,ECH1
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ALLOGRAFT_REJECTION	HALLMARK_ALLOGRAFT_REJECTION	0.0245189657720957	0.0987587356542241	-0.351058538378677	-1.44443947302463	103	up_in_group2	CCL5,F2R,B2M,CXCR3,CCL4,PRKCB,KLRD1,CD7,CD8B,IL16,HLA-A,LTB,CD247,GZMA
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ANDROGEN_RESPONSE	HALLMARK_ANDROGEN_RESPONSE	0.111731843575419	0.26691495965239	-0.357400767741145	-1.28550597275936	49	up_in_group2	B2M,PIAS1,NGLY1,HMGCS1,DNAJB9,ELOVL5,RAB4A,PTK2B,ANKH,SAT1,VAPA,NCOA4,UBE2I,SGK1,ELK4,MYL12A,PDLIM5,ADRM1,TMEM50A,SPCS3
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APICAL_JUNCTION	HALLMARK_APICAL_JUNCTION	0.411637931034483	0.590014367816092	0.281235745095345	1.02051874964812	45	up_in_group1	MYL9,RASA1,LIMA1,GTF2F1,AKT3,RSU1,CTNNA1,SKAP2,MYH9,ACTN4
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APOPTOSIS	HALLMARK_APOPTOSIS	0.135940409683426	0.278354172208921	-0.297699816808779	-1.21044822374047	94	up_in_group2	F2R,IER3,PDCD4,GADD45A,SQSTM1,ISG20,CDKN1B,BAX,SOD2,DDIT3,CDKN1A,BNIP3L,CD2,ENO2,HSPB1,GADD45B,CASP1,GPX4,ANKH,CFLAR,DAP3,PMAIP1,IFNGR1,SAT1,CDC25B,SPTAN1
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_BILE_ACID_METABOLISM	HALLMARK_BILE_ACID_METABOLISM	0.620689655172414	0.684350132625995	-0.301056966582641	-0.896687052427456	22	up_in_group2	HSD17B11,LCK,GCLM,IDH2,ABCA5,SOD1,GSTK1
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_CHOLESTEROL_HOMEOSTASIS	HALLMARK_CHOLESTEROL_HOMEOSTASIS	0.475409836065574	0.633557422969188	0.300501967205145	0.983815393898371	29	up_in_group1	LDLR,CYP51A1,CLU,CD9,ANTXR2
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_COAGULATION	HALLMARK_COAGULATION	0.384615384615385	0.590014367816092	0.336799092512401	1.05075058450125	25	up_in_group1	CRIP2,CLU,CD9,CFD,GSN,CAPN2,FURIN,TIMP1
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_COMPLEMENT	HALLMARK_COMPLEMENT	0.00142291782394832	0.015523150957622	-0.442017205292786	-1.74384638698073	79	up_in_group2	S100A9,GZMK,CCL5,MAFF,GMFB,DPP4,CEBPB,GZMA,DYRK2,APOBEC3G,CTSB,LCK,USP14,SPOCK2,CASP1,CD59,PIM1,STX4,FDX1,KIF2A,IRF7,CD46,CD55
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_DNA_REPAIR	HALLMARK_DNA_REPAIR	0.0733082706766917	0.197015977443609	-0.334091999695237	-1.33912257918369	87	up_in_group2	NME4,TAF10,GTF2B,PNP,POLR2F,EIF1B,GPX4,VPS28,TAF9,MRPL40,NELFCD,GTF2A2,POLE4,POLR1C,SMAD5,SUPT4H1,APRT,POLR2J,SURF1,SDCBP,POLR2K,NME3,AK1,ADRM1,MPC2,PDE4B,TP53,STX3,POLR2C,GUK1,TSG101,EDF1,DAD1,POLR1D,ARL6IP1,SEC61A1,RPA3,RALA
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_E2F_TARGETS	HALLMARK_E2F_TARGETS	0.00405222921286646	0.0348491712306515	0.363224725867057	1.52877286637104	104	up_in_group1	MKI67,MCM5,RAD50,EZH2,TFRC,MTHFD2,ATAD2,SMC4,MCM3,SMC6,EED,ILF3,SYNCRIP,CKS1B,SMC3,NBN,CTCF,PCNA,NME1,PRDX4,GSPT1,TRA2B,SMC1A,RNASEH2A,NUP153,NOLC1,RANBP1,NOP56,PTTG1,ING3,RAD21,BARD1,TBRG4,NUP205,SSRP1,ANP32E,KPNA2
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	0.364605543710021	0.590014367816092	0.302651752353417	1.04435999695284	37	up_in_group1	MYL9,CAPG,TGFBR3,SDC4,AREG,FLNA,TPM4,CALU,FAS
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ESTROGEN_RESPONSE_EARLY	HALLMARK_ESTROGEN_RESPONSE_EARLY	0.540796963946869	0.64595192915876	-0.269972708476572	-0.961710058699588	47	up_in_group2	CHPT1,ABLIM1,BCL2,BAG1,PPIF,UNC119,DYNLT3,ELOVL5,ISG20L2,PMAIP1,NXT1,MED13L,UGCG,MYC
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ESTROGEN_RESPONSE_LATE	HALLMARK_ESTROGEN_RESPONSE_LATE	0.0556621880998081	0.170962434877982	-0.376990297286704	-1.38482776305154	57	up_in_group2	S100A9,CHPT1,PDCD4,PERP,BCL2,ISG20,BAG1,PPIF,DCXR,CXCL14,JAK1,DYNLT3,ELOVL5
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_FATTY_ACID_METABOLISM	HALLMARK_FATTY_ACID_METABOLISM	0.484848484848485	0.633557422969188	-0.255171748040557	-0.979206412304529	70	up_in_group2	ECI1,HSD17B11,HIBCH,ERP29,HMGCS1,GABARAPL1,ENO2,UBE2L6,SDHA,ECHS1,PRDX6,ELOVL5,ECI2,ACO2,ECH1,CBR1,SDHD,ACAA1
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_G2M_CHECKPOINT	HALLMARK_G2M_CHECKPOINT	0.000333612937842454	0.00717267816361276	0.403218333540632	1.6875250164217	100	up_in_group1	MKI67,CENPF,MCM5,WRN,EZH2,SMC2,SAP30,SMC4,BCL3,MCM3,ILF3,SYNCRIP,CKS1B,CTCF,NUP50,NUP98,SLC7A5,GSPT1,TRA2B,CDC27,SMC1A,NOLC1,TFDP1,CUL5,KATNA1,PAFAH1B1,DBF4,PTTG1,SMARCC1,FOXN3,KIF20B,CUL1,RAD21,BARD1,KIF5B,KPNA2,SNRPD1
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_GLYCOLYSIS	HALLMARK_GLYCOLYSIS	0.278195488721804	0.4984335839599	-0.297652384809596	-1.11802392874941	62	up_in_group2	MXI1,IER3,CXCR4,POLR3K,ISG20,RBCK1,ENO2,PPIA,CITED2,HAX1,KIF2A,PRPS1,NDUFV3,SOD1,SLC16A3,ANKZF1
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HEME_METABOLISM	HALLMARK_HEME_METABOLISM	0.0252638626092201	0.0987587356542241	-0.372178184428967	-1.47911735107779	84	up_in_group2	MXI1,FOXO3,EPB41,RBM38,LRP10,ISCA1,MFHAS1,GLRX5,GYPC,CCDC28A,PRDX2,HAGH,ADIPOR1,KDM7A,CTSB,BNIP3L,BPGM,GCLM,LPIN2,VEZF1,EZH1,HTATIP2
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HYPOXIA	HALLMARK_HYPOXIA	0.00626482121755412	0.0448978853924712	-0.391541227300549	-1.55583148932029	83	up_in_group2	PLAC8,MXI1,IER3,FOXO3,MAFF,BTG1,CXCR4,BCL2,ISG20,CDKN1B,PNRC1,KLHL24,S100A4,DDIT3,CDKN1A,BNIP3L,ENO2,PIM1,CITED2,PRKCA,CCNG2
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_IL2_STAT5_SIGNALING	HALLMARK_IL2_STAT5_SIGNALING	0.023917949381217	0.0987587356542241	0.337132074337506	1.40104676592948	95	up_in_group1	TNFRSF18,IL2RA,CSF2,TIAM1,CAPG,AHR,SLC1A5,TNFRSF4,TNFSF10,PHTF2,MAP3K8,PRAF2,HUWE1,GLIPR2,PLEC,BCL2L1,ADAM19,SYT11,CCND2,P2RX4,BATF,PHLDA1,FURIN,AHNAK,TNFRSF9,DCPS,MYO1C
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_IL6_JAK_STAT3_SIGNALING	HALLMARK_IL6_JAK_STAT3_SIGNALING	0.171247357293869	0.334710743801653	0.356327144464623	1.23176133850432	36	up_in_group1	IL2RA,CSF2,MAP3K8,CD9,IL12RB1,PTPN1,FAS
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INFLAMMATORY_RESPONSE	HALLMARK_INFLAMMATORY_RESPONSE	0.593632958801498	0.671742558643801	-0.237918806338252	-0.90805157146108	67	up_in_group2	CCL5,CCR7,IL7R,SELL,CXCR6
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INTERFERON_ALPHA_RESPONSE	HALLMARK_INTERFERON_ALPHA_RESPONSE	0.087360594795539	0.22097091624754	-0.363543134561461	-1.33584680416746	55	up_in_group2	B2M,IFI44,SELL,ISG20,HLA-C,IFI27,UBE2L6,ADAR,CASP1,OGFR,MX1,IRF7,CD74,EIF2AK2,CD47,CNP,ISG15,PSMB9,IFITM3
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INTERFERON_GAMMA_RESPONSE	HALLMARK_INTERFERON_GAMMA_RESPONSE	0.0160588698118784	0.0986473431301103	-0.340381805913073	-1.41993890768522	113	up_in_group2	CCL5,B2M,UPP1,ZBP1,BTG1,HLA-B,IFI44,HLA-A,ISG20,LYSMD2,GZMA,MX2,SOD2,RBCK1,IFI27,CDKN1A,BPGM,UBE2L6,PNP,ADAR,CASP1,PIM1,IL10RA,VAMP5,OGFR,MX1,IRF7,CD74,AUTS2
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_KRAS_SIGNALING_UP	HALLMARK_KRAS_SIGNALING_UP	0.734913793103448	0.770763246425568	0.226699022054715	0.848777897897335	53	up_in_group1	CSF2,ETS1,DOCK2,FBXO4,KCNN4,BIRC3,CCND2,STRN,USP12,IL2RG,ADAM8,TOR1AIP2,CCSER2,LY96
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MITOTIC_SPINDLE	HALLMARK_MITOTIC_SPINDLE	0.00144401404256949	0.015523150957622	0.395749569463718	1.6418328128784	93	up_in_group1	CENPF,TIAM1,TUBGCP3,SOS1,RAPGEF6,LRPPRC,RASA1,SMC4,FLNA,KIFAP3,DOCK2,KIF1B,RASA2,SMC3,GSN,KLC1,CDK5RAP2,CDC27,TUBGCP5,SMC1A,CEP192,MYH9,KATNA1,PCNT,PAFAH1B1,ACTN4,KIF3B,PPP4R2,KIF20B,CD2AP,CAPZB,TUBGCP2,KIF5B
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MTORC1_SIGNALING	HALLMARK_MTORC1_SIGNALING	0.326797385620915	0.562091503267974	0.242572912998077	1.05854452384919	123	up_in_group1	LDLR,CYP51A1,SLC1A5,TFRC,MTHFD2,CD9,ATP2A2,GPI,GSK3B,PSMG1,CTSC,SLA,STIP1,HSPD1,SKAP2,SLC7A5,ALDOA,NAMPT,PGK1,PSMA4,PSMC4,EBP,HSPA4,USO1,TBK1,PRDX1,NUP205,RPN1,PDAP1,PSMD14,RDH11,TXNRD1,P4HA1,PSMC2,PPP1R15A,DAPP1,IMMT,ACLY,ITGB2,CYB5B,PSME3,CANX,HSPA5,SQLE,SLC2A3,ENO1,ACTR2,DDX39A,ACTR3,EDEM1,PDK1,SDF2L1,UCHL5,CALR
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYC_TARGETS_V1	HALLMARK_MYC_TARGETS_V1	1	1	0.146433685675117	0.663234477528255	159	up_in_group1	MCM5,PSMA6,SYNCRIP,DHX15,EIF3J,HNRNPR,NOP16,PCNA,HSPD1,NME1,PRDX4,GSPT1,TRA2B,CCT5,NOLC1,TFDP1,PWP1,RANBP1,NOP56,PGK1,UBE2E1,PSMD1,GNL3,PSMA4,PABPC4,SMARCC1,VDAC1,PSMC4,POLE3,SRPK1,CUL1,SERBP1,KPNA2,TARDBP,SNRPD1,PPM1G,EIF3B,PSMB3,PSMD14,DDX21,HNRNPA3,EIF2S1,GLO1,POLD2,PSMD7,XRCC6,PA2G4
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYC_TARGETS_V2	HALLMARK_MYC_TARGETS_V2	0.378323108384458	0.590014367816092	0.316212425117387	1.04446111471152	30	up_in_group1	MCM5,NOP16,HSPD1,GRWD1,FARSA,NOLC1,NOP56,GNL3,WDR43,TBRG4,MRTO4,DCTPP1
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYOGENESIS	HALLMARK_MYOGENESIS	0.645951035781544	0.69439736346516	-0.257703228285096	-0.884417445693843	38	up_in_group2	GABARAPL2,ABLIM1,BAG1,CDKN1A,MEF2D,GADD45B,EIF4A2,SYNGR2,SPTAN1,IFRD1,TGFB1,ATP6AP1,AK1
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_OXIDATIVE_PHOSPHORYLATION	HALLMARK_OXIDATIVE_PHOSPHORYLATION	0.0233243893715141	0.0987587356542241	-0.307378191722716	-1.32984581037704	153	up_in_group2	ISCA1,UQCRB,ECI1,ISCU,BAX,MRPS22,NQO2,ATP6V1G1,COX7C,UQCR10,OXA1L,MRPS11,NDUFC1,MRPL34,NDUFB5,COX5B,ATP6V0E1,UQCRFS1,COX4I1,SDHA,ECHS1,POLR2F,MPC1,LDHB,GPX4,SLC25A11,ACAT1,OAT,FDX1,ACO2,ECH1,NDUFV2,COX7A2L,SDHD,COX7B,ACAA1,NDUFS2,UQCRH,TIMM9,IDH2,SURF1,NDUFS8,ATP6AP1,SLC25A3,PDHB,PHB2,HTRA2
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_P53_PATHWAY	HALLMARK_P53_PATHWAY	6.00059294038522e-05	0.00258025496436565	-0.461585382287701	-1.88147891825746	99	up_in_group2	F2R,UPP1,IER3,FOXO3,GADD45A,PERP,BTG1,STOM,PITPNC1,CD81,ISCU,BAX,IER5,HDAC3,S100A4,HINT1,EI24,MKNK2,RAP2B,IP6K2,WRAP73,DCXR,DDIT3,CDKN1A,CDKN2AIP,BLCAP,LDHB,CASP1,SLC3A2,CCNG1,IRAK1
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PEROXISOME	HALLMARK_PEROXISOME	0.267441860465116	0.4984335839599	-0.345213051746153	-1.14197979454517	34	up_in_group2	PABPC1,HSD17B11,SOD2,ELOVL5,FIS1,ECI2,ECH1,ACAA1,IDH2,SOD1,GSTK1,VPS4B,CNBP,BCL10
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PI3K_AKT_MTOR_SIGNALING	HALLMARK_PI3K_AKT_MTOR_SIGNALING	0.133208255159475	0.278354172208921	-0.326992081122121	-1.24484880837684	66	up_in_group2	CAMK4,PRKCB,CXCR4,SQSTM1,TNFRSF1A,CDKN1B,EIF4E,MKNK2,DDIT3,LCK,CDKN1A,ARF1
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PROTEIN_SECRETION	HALLMARK_PROTEIN_SECRETION	0.540337711069418	0.64595192915876	-0.248383331838325	-0.945587714535917	66	up_in_group2	ADAM10,SEC22B,M6PR,GNAS,CLTA,ARF1,BNIP3,STX7,STX16,CLN5,SOD1,ATP1A1,PPT1,SNX2,AP2M1,VPS4B,AP3S1,TSG101,RAB2A,VAMP3,RAB14,SCAMP3,CLCN3,GLA,AP2S1,ARFGAP3
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	0.0395648962075706	0.141774211410461	-0.454224162529854	-1.47032460300367	31	up_in_group2	FTL,PRDX2,SOD2,STK25,GCLM,PRDX6,IPCEF1,GPX4,JUNB
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_SPERMATOGENESIS	HALLMARK_SPERMATOGENESIS	0.585271317829457	0.671742558643801	-0.303454447155364	-0.916160251307607	23	up_in_group2	CAMK4,GMCL1
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_TGF_BETA_SIGNALING	HALLMARK_TGF_BETA_SIGNALING	0.126705653021442	0.278354172208921	-0.398343952621087	-1.28944024187181	31	up_in_group2	ID3,ID1,SKIL,FNTA,TGIF1,SMURF2,JUNB,TRIM33,TGFB1,XIAP,UBE2D3,CTNNB1,RHOA,BMPR2,HDAC1,APC,ARID4B
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_TNFA_SIGNALING_VIA_NFKB	HALLMARK_TNFA_SIGNALING_VIA_NFKB	0.0513761467889908	0.169936485532816	-0.329114018581336	-1.35777828329526	104	up_in_group2	CCL5,CCL4,KLF2,IER3,GADD45A,MAFF,BTG1,IL7R,CEBPB,EIF1,SQSTM1,LITAF,PNRC1,IER5,SOD2,CDKN1A,TGIF1,KLF9,PER1
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	0.500952380952381	0.633557422969188	-0.254448178878321	-0.975512871363399	71	up_in_group2	ERN1,SERP1,CEBPB,EIF4E,NPM1,DCP1A,EEF2,IMP3,CNOT2,DNAJB9,EXOSC1,ATF4,HERPUD1,EIF4A2
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UV_RESPONSE_DN	HALLMARK_UV_RESPONSE_DN	0.411392405063291	0.590014367816092	0.268590935350087	1.0257212677567	58	up_in_group1	LDLR,AGGF1,ATP2B1,TGFBR3,SFMBT1,SIPA1L1,AKT3,RASA2,MT1E,RUNX1,RXRA,ACVR2A
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UV_RESPONSE_UP	HALLMARK_UV_RESPONSE_UP	0.911985018726592	0.933698947743892	-0.192709081636213	-0.735502111446375	67	up_in_group2	BTG1,SQSTM1,SOD2,PPIF,STK25,ENO2,MGAT1,PPP1R2,JUNB,NXF1,ARRB2,ACAA1,CNP,CLTB,TMBIM6,AQP3,PPT1,CYB5R1,ATP6V1F,HLA-F
deg_pseudobulk	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_XENOBIOTIC_METABOLISM	HALLMARK_XENOBIOTIC_METABOLISM	0.0646950092421442	0.185459026494147	-0.375569052030988	-1.35629156027772	50	up_in_group2	UPP1,TNFRSF1A,CSAD,SERTAD1,DCXR,GABARAPL1,LPIN2,PGRMC1,ELOVL5,PTGES3,ACO2,ECH1,DDAH2,CBR1,DHPS,TMBIM6,PDLIM5,CYFIP2