analysis	comparison	cell_type	direction	group1	group2	method	source	rank_metric	term_id	term_name	p_value	adjusted_p_value	enrichment_score	normalized_enrichment_score	pathway_size	effect_direction	leading_edge
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ADIPOGENESIS	HALLMARK_ADIPOGENESIS	0.212328767123288	0.390361445783133	0.297423226093783	1.14066408075693	117	up_in_group1	CD36,UCP2,ALDOA,LTC4S,APLP2,UQCRQ,REEP5,ABCA1,COX8A,CD151,SCP2,COX7B,DNAJC15,UQCRC1,CHCHD10,UQCR11,DRAM2,NDUFB7,RTN3,ETFB,IDH3G,DHRS7,NDUFA5,GPX3,IMMT,DECR1,STAT5A,AGPAT3,UQCR10,ECHS1,IDH1,ECH1,FABP4,SDHB,RREB1,PDCD4,PRDX3,MTCH2,PFKL,RAB34,NDUFS3,AK2,GRPEL1,STOM,PLIN2,NMT1,COX6A1,DNAJB9,GHITM,SDHC,CS,MGST3,NDUFAB1,G3BP2,ACAA2,ACADM,MRPL15,YWHAG,SUCLG1
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ALLOGRAFT_REJECTION	HALLMARK_ALLOGRAFT_REJECTION	0.14622641509434	0.35899333826795	-0.328489339285113	-1.21020699889947	105	up_in_group2	RPS19,RPL39,RPS3A,RPS9,RPL9,B2M,CCL22,CD74,HLA-DRA,HLA-DQA1
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ANDROGEN_RESPONSE	HALLMARK_ANDROGEN_RESPONSE	0.662608695652174	0.78466819221968	0.262610577389385	0.904028934103824	65	up_in_group1	MAF,ACTN1,PA2G4,IQGAP2,FKBP5,SLC38A2,SGK1,LMAN1,ANKH,TNFAIP8,GNAI3,CCND3,SPCS3,ZMIZ1,UBE2J1,SEC24D,B4GALT1,ADRM1,NCOA4
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APICAL_JUNCTION	HALLMARK_APICAL_JUNCTION	0.0467128027681661	0.150148294611962	0.381717371116672	1.34990725895624	75	up_in_group1	TGFBI,PTPRC,CD209,TSPAN4,VCAN,EVL,ADAM15,EPB41L2,ACTN1,YWHAH,SKAP2,VASP,RAC2,VCL,MSN,GTF2F1,CD276,ICAM1,SYK,CAP1,CD274,STX4,PECAM1,SIRPA,LIMA1,ADAM9,GNAI2,B4GALT1
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APOPTOSIS	HALLMARK_APOPTOSIS	0.0345533622780177	0.127176174624581	0.373623326443867	1.39294859066453	100	up_in_group1	LMNA,IFITM3,EMP1,CD14,GPX1,TXNIP,CD44,TIMP1,PPT1,SATB1,JUN,LGALS3,SLC20A1,DNAJC3,TIMP2,APP,ANXA1,RARA,CCND2,TNFSF10,ANKH,MCL1,CTNNB1,PPP3R1,DAP,GNA15,BCAP31,BTG2,ROCK1,GPX3,DNM1L,CD69,DPYD,HSPB1
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_BILE_ACID_METABOLISM	HALLMARK_BILE_ACID_METABOLISM	0.819376026272578	0.877902885292048	0.266931442208294	0.767548620271954	28	up_in_group1	ABCA6,ABCA1,SCP2,GSTK1,HSD17B11,RXRA,IDH1
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_CHOLESTEROL_HOMEOSTASIS	HALLMARK_CHOLESTEROL_HOMEOSTASIS	0.338785046728972	0.525700934579439	-0.336702135799049	-1.09754289954298	54	up_in_group2	FABP5,FDPS,HMGCS1,SQLE,ACTG1,FDFT1,PNRC1,IDI1,ACAT2,HMGCR,MVD,S100A11,NFIL3,SCD,TMEM97,DHCR7,PCYT2,SREBF2,ERRFI1,LSS,FASN
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_COAGULATION	HALLMARK_COAGULATION	0.000888502360114	0.0133732838398096	0.537060695111859	1.73354391747659	47	up_in_group1	LGMN,CFD,C1QA,CAPN2,TIMP1,CTSB,PLEK,GNB2,LRP1,CRIP2,DUSP6,PLAU,ANXA1,LAMP2,CTSH,CPQ,PECAM1,A2M,SERPINA1,ADAM9,FURIN,MMP14,FYN
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_COMPLEMENT	HALLMARK_COMPLEMENT	1.67736431113316e-06	7.54813940009924e-05	0.516830043048119	1.96327561022243	111	up_in_group1	MMP12,LGMN,C1QC,C1QA,CD36,FCER1G,CTSC,LIPA,TIMP1,ITGAM,CTSB,CTSS,PLEK,GNG2,GCA,HSPA5,CTSL,GNB2,LRP1,DUSP6,JAK2,PLAUR,PLSCR1,USP15,CTSD,CD59,LGALS3,HSPA1A,TIMP2,CPM,PRCP,LCP2,LAP3,SH2B3,LAMP2,CTSH,GNB4,CPQ,GNAI3,STX4,GRB2,RHOG,PPP4C,ANXA5,SERPINA1,ADAM9,WAS,GNAI2,MMP14,FYN,DGKH,USP16
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_DNA_REPAIR	HALLMARK_DNA_REPAIR	0.487931034482759	0.665360501567398	0.263943386014809	0.991332083720222	102	up_in_group1	NME1,POLE4,TMED2,RNMT,GTF2F1,XPC,VPS28,POLR2G,ARL6IP1,SDCBP,BCAP31,HCLS1,NELFE,SUPT5H,GUK1,SRSF6,POLR3GL,ADRM1,ITPA,UPF3B,POLR2F,SUPT4H1,DAD1,DUT,NCBP2,RPA3,POLR2H,POLD4,SMAD5,GTF2H5,MPG,DCTN4,POLR2I,DGUOK,REV3L,CSTF3,APRT,POLR2J,DDB1,POLD3,AGO4,MRPL40,CETN2,SEC61A1
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_E2F_TARGETS	HALLMARK_E2F_TARGETS	0.404844290657439	0.587677196115638	0.276966063659762	1.04189999110003	104	up_in_group1	DNMT1,PA2G4,TRA2B,RANBP1,NME1,POLE4,HNRNPD,DEK,ILF3,NASP,SYNCRIP,PNN,TUBB,SMC1A,GSPT1,SNRPB,RBBP7,RFC1,STMN1,NAA38,LYAR,NOP56,NBN,SRSF1,SMC3,BRCA2,DCTPP1,NOLC1,LUC7L3,ANP32E,XRCC6,DUT,RPA3,AK2,SRSF2,PRPS1,EED,XPO1,RAD21,PAICS,SMC4,PDS5B,PRKDC,POLD3,USP1,EXOSC8,CDK4
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	0.00118873634131641	0.0133732838398096	0.514485612734158	1.70091485259112	52	up_in_group1	DAB2,PMP22,EMP3,TGFBI,CD44,TIMP1,TPM1,VCAN,TGFB1,ANPEP,LRP1,PPIB,PLAUR,GLIPR1,CD59,JUN,QSOX1,PLOD3,CALU,COLGALT1
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ESTROGEN_RESPONSE_EARLY	HALLMARK_ESTROGEN_RESPONSE_EARLY	0.370434782608696	0.555652173913044	0.307548216661048	1.05872539201407	65	up_in_group1	BLVRB,CD44,RAB31,XBP1,JAK2,AQP3,MYOF,FKBP5,FOS,RARA,NCOR2,SLC39A6,KLF10,ELF1
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ESTROGEN_RESPONSE_LATE	HALLMARK_ESTROGEN_RESPONSE_LATE	0.858620689655172	0.89444092492873	0.222265028542011	0.795044761559307	79	up_in_group1	BLVRB,CD44,RAB31,SNX10,XBP1,JAK2,PTPN6,MYOF,FKBP5,FOS,SGK1,NCOR2,MOCS2,ATP2B4,ETFB,TIAM1,SERPINA1,RABEP1,DNAJC1,KLF4,AFF1,AREG,PDCD4,ZFP36
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_FATTY_ACID_METABOLISM	HALLMARK_FATTY_ACID_METABOLISM	0.207612456747405	0.390361445783133	0.312737754750895	1.16153869109332	94	up_in_group1	CD36,ALDOA,XIST,LTC4S,MIF,BLVRA,YWHAH,GLUL,IL4I1,HSD17B10,OSTC,APEX1,IDH3G,HSD17B11,DECR1,HADHB,PSME1,ECHS1,IDH1,ECH1,IDH3B,NBN,SERINC1,UBE2L6,SUCLG2,CPT1A,UROD,ADSL,SDHC,HSPH1,ERP29,ACAA2,MDH1,ACADM,SUCLG1,ELOVL5,SDHA,PDHA1,UROS,ACSL4,RAP1GDS1,SDHD,GABARAPL1,EPHX1
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_G2M_CHECKPOINT	HALLMARK_G2M_CHECKPOINT	0.778169014084507	0.869565217391304	0.224600457579497	0.838637723279849	101	up_in_group1	TGFB1,NCL,TRA2B,HNRNPD,ILF3,NASP,ATF5,SYNCRIP,HNRNPU,SNRPD1,RASAL2,HIF1A,SMC1A,AMD1,FOXN3,GSPT1,STMN1,KIF5B,SRSF10,EWSR1,SRSF1,BRCA2,CUL5,CDC27,NOLC1,CBX1,RAD23B,CUL4A,SFPQ,SRSF2,TLE3,ARID4A,MTF2,XPO1,RAD21,SMC4,PDS5B,ATRX
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_GLYCOLYSIS	HALLMARK_GLYCOLYSIS	0.167530224525043	0.35899333826795	0.326984901544834	1.18831346930308	85	up_in_group1	TGFBI,CD44,ALDOA,VCAN,MIF,SDC2,PFKP,HSPA5,UGP2,QSOX1,EGLN3,P4HA1,NASP,GNPDA1,PGK1,NDUFV3,AKR1A1,SLC16A3,PSMC4,GALK1,GLRX
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HEME_METABOLISM	HALLMARK_HEME_METABOLISM	0.101045296167247	0.284189895470383	0.3371471852284	1.25307069371784	96	up_in_group1	BLVRB,UCP2,CTSB,BLVRA,PICALM,USP15,GYPC,AQP3,MPP1,BACH1,LAMP2,KDM7A,CAST,CCND3,RNF19A,SDCBP,TNRC6B,ACP5,BTG2,TMEM9B,LMO2,NR3C1,SEC14L1,SNCA,NCOA4,CLIC2,PSMD9
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HYPOXIA	HALLMARK_HYPOXIA	0.247848537005164	0.428968621739706	0.297659688760026	1.12998404388034	106	up_in_group1	S100A4,TGFBI,ALDOA,SLC2A3,MIF,SDC2,PFKP,HSPA5,UGP2,PLAUR,JUN,WSB1,FOS,P4HA1,PGK1,NAGK,GAA,HK1,GALK1,GLRX,DUSP1,FBP1,NR3C1,BHLHE40,ZNF292,GPI
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_IL2_STAT5_SIGNALING	HALLMARK_IL2_STAT5_SIGNALING	0.00113019820229732	0.0133732838398096	0.446854861712742	1.67832036964681	102	up_in_group1	IFITM3,EMP1,SCN9A,FGL2,CD44,NRP1,IL1R2,AHNAK,BATF3,PLEC,SLC2A3,GLIPR2,XBP1,GSTO1,PLSCR1,ANXA4,LTB,MYO1E,GALM,PHTF2,P4HA1,CTSZ,CCND2,RNH1,TNFSF10,ADAM19,CCND3,PRNP,AHR,MAP3K8,LRRC8C,IRF8
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_IL6_JAK_STAT3_SIGNALING	HALLMARK_IL6_JAK_STAT3_SIGNALING	0.00838986023682998	0.0539348158081927	0.471685945134674	1.55941703709528	52	up_in_group1	CD36,CD14,CD44,IL1R2,CCR1,TGFB1,SOCS3,PTPN2,JUN,LTB,TNFRSF1A,CSF2RB,IRF9,CBL,ITGA4,GRB2,MAP3K8,A2M,LTBR,STAT2,IFNAR1,STAT1,PTPN11,PDGFC
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INFLAMMATORY_RESPONSE	HALLMARK_INFLAMMATORY_RESPONSE	0.0558432283221285	0.167529684966386	0.370634916558151	1.35983816035034	90	up_in_group1	CD14,STAB1,MARCO,PTPRE,EMP3,MSR1,TIMP1,CYBB,CCL2,CD40,BST2,CALCRL,ABCA1,PLAUR,C3AR1,IFITM1,TAPBP,PTAFR,LCP2,TNFSF10,ICAM1,GNAI3,LY6E,AHR,ATP2B1,HIF1A,GNA15,RHOG
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INTERFERON_ALPHA_RESPONSE	HALLMARK_INTERFERON_ALPHA_RESPONSE	0.158813263525305	0.35899333826795	0.363167699871301	1.21827796637025	58	up_in_group1	IFITM3,IFI30,IFITM2,TXNIP,BST2,PARP14,LPAR6,IFI27,PLSCR1,CD47,IFITM1,IRF9,LAP3,PARP9,ELF1,LY6E,ISG15,PSMB8,PSME2,IFI35,SP110
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INTERFERON_GAMMA_RESPONSE	HALLMARK_INTERFERON_GAMMA_RESPONSE	0.00584261053034434	0.0438195789775825	0.391545797920351	1.50900013592048	121	up_in_group1	IFITM3,IFI30,IFITM2,P2RY14,FGL2,TXNIP,CCL2,CD40,BST2,PSMB10,PFKP,PARP14,VAMP5,RNF213,JAK2,SOCS3,IFI27,PTPN2,PLSCR1,PTPN6,VAMP8,CSF2RB,IRF9,TAPBP,SAMHD1,APOL6,LCP2,LAP3,TNFSF10,ICAM1,MVP,LY6E,ISG15,HLA-DMA,PSMB8,CD274,HIF1A,IRF8,PSME2,IFI35,SP110,STAT2,PSMA2,IRF5,UPP1,STAT1,CD69,PSME1
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_KRAS_SIGNALING_DN	HALLMARK_KRAS_SIGNALING_DN	0.738341968911917	0.851933041052212	-0.315311573897098	-0.803345432874625	20	up_in_group2	CALML5,SERPINB2,LYPD3,PKP1,CHST2,SYNPO,SNN
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_KRAS_SIGNALING_UP	HALLMARK_KRAS_SIGNALING_UP	0.022092270517287	0.094035806228208	0.396451622917954	1.44076622869963	85	up_in_group1	F13A1,EMP1,FCER1G,CLEC4A,NRP1,CTSS,MAFB,LAPTM5,ITGB2,LY96,DUSP6,DOCK2,PLAUR,SATB1,GYPC,C3AR1,EVI5,PLAU,CCND2,CD37,CBL,ANKH,PSMB8,GLRX,LAT2,IRF8,PECAM1
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MITOTIC_SPINDLE	HALLMARK_MITOTIC_SPINDLE	0.216867469879518	0.390361445783133	0.303200015890266	1.15157276197269	107	up_in_group1	EPB41L2,DOCK2,MYO1E,VCL,ARHGAP4,ARF6,RASAL2,SMC1A,TIAM1,DST,RFC1,KLC1,EZR,MAP1S,ROCK1,PCM1,AKAP13,ARHGAP10,CAPZB,KIF5B,WASF2,HOOK3,CCDC88A,ARHGDIA,KIF1B,SMC3,BRCA2,CDC27,RASA2,ABI1,RHOT2,DYNC1H1,NIN,NF1,MAP3K11,CDC42,MYH9,SUN2,YWHAE,UXT,SMC4,PDLIM5,ARL8A,STAU1,PREX1,APC,MYO9B,TUBGCP3,MAPRE1,CNTRL,PCGF5,TUBGCP2,FLNA,RABGAP1,STK38L,KIF22,CSNK1D,CLIP1,ARHGEF7,RAB3GAP1
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MTORC1_SIGNALING	HALLMARK_MTORC1_SIGNALING	0.137254901960784	0.35899333826795	0.301214288362808	1.19768564227272	152	up_in_group1	LGMN,IFI30,CTSC,FGL2,ALDOA,SLA,ITGB2,SLC2A3,HSP90B1,HSPA5,SKAP2,SSR1,XBP1,CANX,FKBP2,CORO1A,CALR,SDF2L1,EGLN3,RPN1,P4HA1,HSPD1,PSMA4,PGK1,EIF2S2,RAB1A,BCAT1,PSMC4,GLRX,HSPA9,UFM1,ACTR2,BTG2,CYP51A1,IMMT,BHLHE40,CYB5B,GPI,ATP6V1D,IDH1,PSMD14,HSPE1,PSMD13,USO1,SEC11A,PFKL,PSME3,PNO1,PSMC2,CCT6A
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYC_TARGETS_V1	HALLMARK_MYC_TARGETS_V1	0.00307110347195281	0.0276399312475753	-0.399145929328147	-1.58608881742681	173	up_in_group2	RPL34,RPS6,RPS2,RPS3,RPL14,RPL18,RPL6,RPS5,RACK1,RPL22,RPLP0,RPS10
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYC_TARGETS_V2	HALLMARK_MYC_TARGETS_V2	0.29635761589404	0.476289025543992	0.386540441031519	1.13309036079743	30	up_in_group1	PA2G4,DDX18,CBX3,HSPD1,GNL3,WDR43,TCOF1,NOP56,DCTPP1,HSPE1,NOLC1,IMP4,SRM,MPHOSPH10,PES1,CDK4,MRTO4,NIP7,GRWD1,FARSA,WDR74
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYOGENESIS	HALLMARK_MYOGENESIS	0.162872154115587	0.35899333826795	0.362125635372383	1.21103640517615	57	up_in_group1	CFD,CD36,MEF2C,TGFB1,RB1,TPM3,MEF2A,PLXNB2,APP,IGFBP7,GAA,PRNP
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_OXIDATIVE_PHOSPHORYLATION	HALLMARK_OXIDATIVE_PHOSPHORYLATION	0.185267857142857	0.378956980519481	-0.28828888946019	-1.14822531835665	174	up_in_group2	ATP5F1E,ATP5MG,SLC25A6,ATP5MF,ATP5MC2,ATP5ME,ATP5PF,ATP5F1B,ATP5F1D,ATP5MC3,ATP5PD,GPX4,ATP5F1C,ISCU,ATP5PO,CYB5A,ATP5MC1
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_P53_PATHWAY	HALLMARK_P53_PATHWAY	0.0132858932734329	0.0664294663671642	-0.406966210949781	-1.51860916690626	115	up_in_group2	RPS12,RPL36,RPL18,RPS27L,RACK1,PERP,GADD45A,SLC7A11,ISCU,KRT17,HINT1,SFN,CDKN2A,BTG1,SAT1,IER3
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PEROXISOME	HALLMARK_PEROXISOME	0.991452991452991	0.991452991452991	0.164032751055183	0.534618268917136	49	up_in_group1	YWHAH,SCP2,MVP,CTBP1,GSTK1,HSD17B11,VPS4B,IDH1,ECH1,TSPO,ATXN1,CNBP,CLN8,BCL10,ELOVL5,ACSL4,ITGB1BP1,SLC25A19,PEX2,PRDX5,SMARCC1,CAT,HMGCL
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PI3K_AKT_MTOR_SIGNALING	HALLMARK_PI3K_AKT_MTOR_SIGNALING	0.597902097902098	0.744749895693292	0.269356919386244	0.939301193736373	71	up_in_group1	SLA,HSP90B1,CLTC,MKNK1,CALR,RALB,TNFRSF1A,ARPC3,CSNK2B,ITPR2,GRB2,ACTR2,TIAM1,PPP1CA,STAT2,IRAK4,YWHAB,DUSP3,PTPN11,MAPK1,UBE2N,ARHGDIA,AP2M1,IL2RG
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PROTEIN_SECRETION	HALLMARK_PROTEIN_SECRETION	0.0229865304113397	0.094035806228208	0.397888985937754	1.40311190364639	74	up_in_group1	CTSC,PPT1,CD63,SNX2,ABCA1,CLTC,ARFGAP3,TMED2,STX12,LMAN1,TMED10,VAMP3,LAMP2,AP3S1,COPB1,AP2B1,AP2S1,RAB5A,RER1,CLTA,ATP1A1,DST,SEC24D,SNAP23,DNM1L,VPS4B,RAB2A,TMX1,MAPK1,KIF1B,AP2M1,USO1,ANP32E,GOLGA4,ARCN1,COPE,STX16,YIPF6
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	0.0106980035201239	0.060176269800697	-0.555836628908379	-1.69926326809075	39	up_in_group2	TXN,FTL,SELENOS,NQO1,GPX4,TXNRD1,ATOX1,LSP1,PRDX1,GCLM,G6PD
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_SPERMATOGENESIS	HALLMARK_SPERMATOGENESIS	0.792270531400966	0.869565217391304	0.272802286755763	0.776990645603785	26	up_in_group1	ALOX15,TLE4
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_TGF_BETA_SIGNALING	HALLMARK_TGF_BETA_SIGNALING	0.285950413223141	0.476289025543992	0.381196580562847	1.15003462647939	34	up_in_group1	TGFB1,FKBP1A,RAB31,SLC20A1,NCOR2,CTNNB1,KLF10,PPP1CA,FURIN,ENG,TGFBR1,PMEPA1,ARID4B,FNTA,SMURF2,RHOA,SKIL,PPP1R15A
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_TNFA_SIGNALING_VIA_NFKB	HALLMARK_TNFA_SIGNALING_VIA_NFKB	0.610599078341014	0.744749895693292	-0.238610871364847	-0.918271790901425	141	up_in_group2	SQSTM1,BIRC3,DUSP5,CCL20,GADD45A,BCL2A1,EGR1,BTG1,MARCKS,SERPINB2,SAT1,PNRC1,KYNU,IER3,IL7R,EIF1,BTG3,CD83,TNFRSF9,TRAF1,TGIF1,ID2,EFNA1,IFNGR2,TRIP10,PLK2,TNFAIP3,NFIL3,PHLDA1,SDC4,RELB,SNN,IL18,SOD2,IRS2,MSC
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	0.874564459930314	0.89444092492873	0.217937824117409	0.783812798752983	82	up_in_group1	CCL2,HSP90B1,PDIA6,HSPA5,SSR1,XBP1,CALR,EIF4EBP1,DNAJC3,EIF4G1,FUS,BANF1,SPCS3,HSPA9,ATF6
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UV_RESPONSE_DN	HALLMARK_UV_RESPONSE_DN	0.0367397837804345	0.127176174624581	0.426288664160346	1.43685786429731	60	up_in_group1	DAB2,PMP22,NRP1,SDC2,RUNX1,ANXA4,TGFBR2,SIPA1L1,ATP2B1,ATP2B4,ZMIZ1,DUSP1,SPOP,NR3C1,FYN,BHLHE40,RXRA,CELF2,AGGF1,RASA2,MRPS31,MGMT
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UV_RESPONSE_UP	HALLMARK_UV_RESPONSE_UP	0.612349914236707	0.744749895693292	0.254152971448535	0.932302955603281	89	up_in_group1	PPT1,ALDOA,DDX21,AQP3,RPN1,MGAT1,FOS,PSMC3,ICAM1,POLE3,HNRNPU,NR4A1,CCND3,ATP6V1F,CDC5L,AP2S1,AMD1,BTG2,TMBIM6,FURIN,MMP14,GPX3,CYB5B,DNAJB1,EIF2S3
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_WNT_BETA_CATENIN_SIGNALING	HALLMARK_WNT_BETA_CATENIN_SIGNALING	0.464898595943838	0.653763650546022	0.406570257258331	1.02176071803103	16	up_in_group1	CCND2,NCOR2,CTNNB1,HDAC2
deg_findmarkers	AtopicDermatitis vs Control	dccell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_XENOBIOTIC_METABOLISM	HALLMARK_XENOBIOTIC_METABOLISM	0.513698630136986	0.679895245769541	0.266657651010557	0.978595032817298	88	up_in_group1	CD36,BLVRB,PSMB10,MAN1A1,NINJ1,DDAH2,GSTO1,SPINT2,TNFRSF1A,PDK4,COMT,CNDP2,BCAT1,IRF8,SLC35B1,FBP1,TMBIM6,DHRS7,UPP1,ETS2,IDH1,ECH1,NDRG2,SAR1B
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ADIPOGENESIS	HALLMARK_ADIPOGENESIS	0.916981132075472	1	-0.195078465579683	-0.750476725576683	60	up_in_group2	CHCHD10,APOE,GPX3,SSPN,PHLDB1,PRDX3,ECH1,OMD,C3
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ALLOGRAFT_REJECTION	HALLMARK_ALLOGRAFT_REJECTION	0.439209726443769	0.677114994934144	0.381490729793874	1.03415264542112	21	up_in_group1	EIF5A,CAPG,CD47,EIF3J,NME1,THY1,CCL2
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ANDROGEN_RESPONSE	HALLMARK_ANDROGEN_RESPONSE	0.650746268656716	0.891763405196241	0.309031696421807	0.865985374354184	24	up_in_group1	UAP1,DBI,PA2G4,AKAP12,ADRM1,XRCC6,UBE2I,MYL12A,STEAP4,XRCC5,SMS,ARID5B,TMEM50A,FKBP5
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APICAL_JUNCTION	HALLMARK_APICAL_JUNCTION	0.492857142857143	0.701373626373626	0.313278363379116	0.978055827238928	39	up_in_group1	VCAN,CD34,TGFBI,FBN1,EPB41L2,YWHAH,ITGB1,CERCAM,THBS3,PFN1,ARPC2,THY1,MYL12B,MPZL1,CAP1,SGCE,MSN,PTEN
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APOPTOSIS	HALLMARK_APOPTOSIS	0.275524475524476	0.50972027972028	0.347056229422104	1.12562950889934	46	up_in_group1	IGFBP6,GSN,DNAJA1,ANXA1,CTNNB1,CLU,RHOB,LMNA,EMP1,LGALS3,CD44
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_COAGULATION	HALLMARK_COAGULATION	0.396848137535817	0.638407873427183	0.334198263700467	1.03557713523506	37	up_in_group1	F10,GSN,FBN1,CFH,FN1,ANXA1,CLU,CPQ,CRIP2,CD9
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_COMPLEMENT	HALLMARK_COMPLEMENT	0.0394922425952045	0.193283582089552	0.449677858389769	1.4447902200027	45	up_in_group1	CD55,F10,CFH,COL4A2,FN1,CLU,CPQ,CTSL,ATOX1,LGALS3,PFN1,CD59,HSPA5,ANXA5,APOC1,PLSCR1
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_DNA_REPAIR	HALLMARK_DNA_REPAIR	1	1	0.117564852499052	0.383727818152022	47	up_in_group1	COX17,NME1,RBX1,ADRM1,SDCBP,APRT,MPG,GPX4,CETN2,DAD1,POLR1D,ERCC1,SRSF6,DGUOK,POLR2J,REV3L,EIF1B,GTF2A2,GUK1,POLR3GL,POLR2E
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_E2F_TARGETS	HALLMARK_E2F_TARGETS	0.988538681948424	1	0.169520411707136	0.525291365597534	37	up_in_group1	STAG1,TUBB,DEK,PA2G4,NME1
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	0.00457018918998418	0.0563656666764715	0.428176613973599	1.55265686558225	96	up_in_group1	POSTN,PCOLCE2,IL32,ABI3BP,MFAP5,VCAN,BASP1,ECM1,TGFBI,FBN1,EMP3,COL6A3,COL4A1,ANPEP,CAPG,COL4A2,FN1,COL3A1,DAB2,NNMT,SERPINH1,COL5A2,IGFBP3,RHOB,ITGB1,FSTL1,PMP22,TPM1,CALU,DPYSL3,CD44,PPIB,CD59,FBLN2,NT5E,MXRA5,TPM4,COL5A1
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ESTROGEN_RESPONSE_EARLY	HALLMARK_ESTROGEN_RESPONSE_EARLY	0.331325301204819	0.583763625932301	-0.343061864778245	-1.07097795323269	24	up_in_group2	PRSS23,SVIL,GJA1,RHOBTB3,SH3BP5,CXCL12,OLFML3
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ESTROGEN_RESPONSE_LATE	HALLMARK_ESTROGEN_RESPONSE_LATE	0.694968553459119	0.907187639946261	-0.255460382992299	-0.858061878465551	33	up_in_group2	MDK,PRSS23,CXCL12,COX6C,EMP2
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_FATTY_ACID_METABOLISM	HALLMARK_FATTY_ACID_METABOLISM	0.95702005730659	1	0.202007604530694	0.625959135990866	37	up_in_group1	S100A10,YWHAH,LDHA,UGDH
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_G2M_CHECKPOINT	HALLMARK_G2M_CHECKPOINT	0.711038961038961	0.907187639946261	-0.246910753084166	-0.846481990916846	36	up_in_group2	MEIS2,MARCKS,NUMA1,PURA,SRSF1
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_GLYCOLYSIS	HALLMARK_GLYCOLYSIS	0.000121883612861016	0.00450969367585759	0.602922272638382	1.92660551011293	42	up_in_group1	VCAN,TGFBI,UGP2,SDC2,KDELR3,TXN,LDHA,IGFBP3,ANGPTL4,ARPP19,ENO1,PKM,CD44,IL13RA1,PPIA,PAM,NT5E,HDLBP,TPST1,HSPA5,COL5A1,PSMC4
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HEME_METABOLISM	HALLMARK_HEME_METABOLISM	0.876923076923077	1	-0.219554237153134	-0.729429284066903	31	up_in_group2	PRDX2,BNIP3L,SELENBP1,NR3C1,ADD1,CTSB,C3,LRP10
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HYPOXIA	HALLMARK_HYPOXIA	0.0576923076923077	0.194055944055944	0.41755690612746	1.38265435488013	52	up_in_group1	ACKR3,TGFBI,UGP2,MT2A,FOS,SDC2,KDELR3,LDHA,IGFBP3,MT1E,ANXA2,ANGPTL4,KLF6,ENO1,AKAP12,PAM,HDLBP,HSPA5,PLIN2,COL5A1
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_IL2_STAT5_SIGNALING	HALLMARK_IL2_STAT5_SIGNALING	0.0183480682719313	0.136037647652404	0.512018906995822	1.5643349865985	34	up_in_group1	FGL2,ECM1,CAPG,GLIPR2,CTSZ,RHOB,ANXA4,RNH1,KLF6,EMP1,NRP1,CD44,NT5E,GSTO1,SNX9,PLIN2,SERPINB6,XBP1,PLSCR1
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INFLAMMATORY_RESPONSE	HALLMARK_INFLAMMATORY_RESPONSE	0.0701492537313433	0.199655568312285	0.507733863972984	1.42279936121761	24	up_in_group1	TNFAIP6,CD55,HAS2,NAMPT,EMP3,AXL
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INTERFERON_ALPHA_RESPONSE	HALLMARK_INTERFERON_ALPHA_RESPONSE	0.807462686567164	0.995870646766169	0.274208226017056	0.7684011575766	24	up_in_group1	PROCR,CD47,NCOA7,PARP14
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INTERFERON_GAMMA_RESPONSE	HALLMARK_INTERFERON_GAMMA_RESPONSE	0.241620111731844	0.496663563004345	0.360770835407883	1.15686456463737	43	up_in_group1	TNFAIP6,FGL2,NAMPT,CFH,MT2A,MVP
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_KRAS_SIGNALING_UP	HALLMARK_KRAS_SIGNALING_UP	0.0417910447761194	0.193283582089552	0.528687429596903	1.48151657883957	24	up_in_group1	SLPI,CFH,IGFBP3,CAB39L,ANGPTL4,GNG11,EMP1,KLF4,NRP1,AKAP12,GYPC
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MITOTIC_SPINDLE	HALLMARK_MITOTIC_SPINDLE	0.217142857142857	0.48399835458659	0.378929104381907	1.18282167543646	38	up_in_group1	GSN,EPB41L2,CDC42,YWHAE,SPTBN1,CTTN,ARF6,ARHGDIA,CAPZB,CLIP1,DYNC1H1,BIN1
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MTORC1_SIGNALING	HALLMARK_MTORC1_SIGNALING	0.000579583705616231	0.0107222985539003	0.543190579492191	1.79866458737359	52	up_in_group1	FGL2,NAMPT,RPN1,EIF2S2,PPA1,CALR,SERPINH1,LDHA,PITPNB,TCEA1,CCT6A,CD9,ENO1,PDAP1,PPIA,SDF2L1,HSPA5,PSMC4,UFM1,HSP90B1,XBP1,PRDX1,PSMC6
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYC_TARGETS_V1	HALLMARK_MYC_TARGETS_V1	0.215736040609137	0.48399835458659	0.30946822335613	1.14290526729653	108	up_in_group1	EIF2S2,YWHAE,LDHA,SET,EIF3J,GNL3,PWP1,DDX21,DEK,SNRPG,PA2G4,HNRNPA1,NME1,HNRNPA3,PPIA,PSMD7,PSMC4,CCT5,SRSF3,PSMC6,CBX3,SNRPD1,PSMB3,XRCC6,ERH,CCT2,RAN,PSMB2,VDAC1,EIF4H,PSMD8,LSM7,SYNCRIP,SNRPD3,PGK1,C1QBP,GLO1,PRDX4,SRM,YWHAQ,PSMA6,HNRNPC,NHP2,NOP56,KPNB1,RANBP1,RNPS1,HDAC2,NPM1,HSPE1,HNRNPU,PSMA4,BUB3,CCT7,PPM1G,RAD23B,APEX1
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYOGENESIS	HALLMARK_MYOGENESIS	0.0220601590787682	0.136037647652404	-0.419064388098571	-1.54252870795715	50	up_in_group2	TAGLN,TPM2,IGF1,PRNP,CRYAB,AEBP1,SVIL,WWTR1,GPX3,GADD45B,SSPN,SOD3,SORBS3,IGFBP7,HSPB2,MYH9,FXYD1,MEF2C
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_OXIDATIVE_PHOSPHORYLATION	HALLMARK_OXIDATIVE_PHOSPHORYLATION	1	1	0.134920246003436	0.489172076946302	94	up_in_group1	LDHA,NDUFC2,GLUD1,COX17,TIMM10,UQCRFS1,PDK4,TIMM13,TIMM8B,CYB5R3,HSD17B10,COX6A1,MGST3,HADHA,VDAC1,GPX4,NDUFA1,NDUFS6,NDUFA3,ACAT1
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_P53_PATHWAY	HALLMARK_P53_PATHWAY	0.458823529411765	0.679058823529412	0.340746232633102	1.00996690964375	30	up_in_group1	PROCR,ZBTB16,FOS,S100A10
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PEROXISOME	HALLMARK_PEROXISOME	0.0555555555555556	0.194055944055944	0.526406871685188	1.44531191561834	22	up_in_group1	CRABP2,HSD3B7,SEMA3C,YWHAH,MVP
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PI3K_AKT_MTOR_SIGNALING	HALLMARK_PI3K_AKT_MTOR_SIGNALING	0.0537313432835821	0.194055944055944	0.516569095104033	1.44755792490903	24	up_in_group1	CALR,CAB39L,ARHGDIA,CFL1,PFN1,YWHAB,TNFRSF1A,HSP90B1,CSNK2B,ARPC3,PPP1CA,ACTR3,PTEN
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PROTEIN_SECRETION	HALLMARK_PROTEIN_SECRETION	0.912721893491124	1	0.229302983357896	0.674049627760605	29	up_in_group1	AP2B1,COPB1,COPE,PAM
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	0.350148367952522	0.588885891556515	-0.358105054528638	-1.05968515073676	20	up_in_group2	PRNP,PRDX2,GPX3,FTL
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_TNFA_SIGNALING_VIA_NFKB	HALLMARK_TNFA_SIGNALING_VIA_NFKB	0.0211121760680312	0.136037647652404	0.486290661296017	1.50686447122851	37	up_in_group1	TNFAIP6,TUBB2A,ACKR3,NAMPT,CEBPD,FOS,HES1,RHOB,KLF6,KLF4,CD44,JUNB,CCL2,CFLAR,NFE2L2
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	0.0673352435530086	0.199655568312285	0.462707897615773	1.42147323306719	35	up_in_group1	TUBB2A,EIF4G1,KDELR3,CALR,NABP1,HSPA5,LSM1,HSP90B1,CCL2,XBP1,HERPUD1,YWHAZ,PAIP1,PDIA6,KIF5B,DNAJC3
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UV_RESPONSE_DN	HALLMARK_UV_RESPONSE_DN	0.222377622377622	0.48399835458659	0.367966897968891	1.18116469269973	44	up_in_group1	HAS2,TGFBR2,RND3,SDC2,COL3A1,DAB2,COL5A2,MT1E,EFEMP1,ANXA4,ANXA2,PMP22,NRP1
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UV_RESPONSE_UP	HALLMARK_UV_RESPONSE_UP	0.115384615384615	0.304945054945055	0.449058984125735	1.32003533778743	29	up_in_group1	DNAJA1,RPN1,FOS,PSMC3,RHOB,DDX21,PDAP1,CLTB,JUNB,UROD,MGAT1
deg_findmarkers	AtopicDermatitis vs Control	fibroblasts	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_XENOBIOTIC_METABOLISM	HALLMARK_XENOBIOTIC_METABOLISM	0.264900662251656	0.50972027972028	-0.32508731273495	-1.12529914362085	38	up_in_group2	PTGDS,IGF1,APOE
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ADIPOGENESIS	HALLMARK_ADIPOGENESIS	0.0513080880775489	0.225755587541215	0.30960799484829	1.36002747071898	94	up_in_group1	SPARCL1,UQCRQ,UQCR11,NMT1,COX6A1,NDUFB7,ALDOA,COX8A,MGST3,NDUFA5,UQCR10,ANGPTL4,NDUFAB1,DNAJC15,IFNGR1,UQCRC1,HIBCH,PDCD4,CHCHD10,PFKL,SCP2,ECHS1,NDUFS3,ETFB,AK2,SDHC,APLP2,CYC1,ALDH2,SOD1,DECR1,MRPL15,ARL4A,COX7B,ECH1,SDHB,GHITM,MTCH2,GPX4,ATP1B3,REEP5,PRDX3,IDH3G
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ALLOGRAFT_REJECTION	HALLMARK_ALLOGRAFT_REJECTION	0.263227513227513	0.609579504316347	-0.403464018633586	-1.17035280114501	48	up_in_group2	RPS19,RPL39,RPL9,RPS9,RPS3A
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ANDROGEN_RESPONSE	HALLMARK_ANDROGEN_RESPONSE	0.563899868247694	0.845965770171149	-0.316246732072533	-0.920446555180066	49	up_in_group2	ARID5B,HMGCS1,ALDH1A3,ELL2,IDI1,AZGP1,HPGD,RPS6KA3,INSIG1,HMGCR,SGK1,SMS,STEAP4,DHCR24,ELOVL5
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APICAL_JUNCTION	HALLMARK_APICAL_JUNCTION	0.770618556701031	0.941867124856816	-0.265231923470103	-0.790161329494328	56	up_in_group2	CDSN,CLDN4,NECTIN4,WASL,MAP3K20,CRB3,INSIG1,DSC1,TJP1,ADAM9,ACTG1,GRB7,ACTB
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APOPTOSIS	HALLMARK_APOPTOSIS	0.416361416361416	0.806245256424157	-0.328159669700297	-1.03395052705923	78	up_in_group2	GADD45A,GADD45B,IER3,CDKN1A,ATF3,SQSTM1,PMAIP1,ISG20,CYLD,DNAJA1,BNIP3L,DDIT3,EREG
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_BILE_ACID_METABOLISM	HALLMARK_BILE_ACID_METABOLISM	0.942028985507246	1	0.209983328030728	0.635493555257163	20	up_in_group1	IDH2,PRDX5,GSTK1,SCP2,CROT,SOD1,OPTN
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_CHOLESTEROL_HOMEOSTASIS	HALLMARK_CHOLESTEROL_HOMEOSTASIS	0.712290502793296	0.895450917797286	-0.295171998793709	-0.813666843046944	36	up_in_group2	ATF3,HMGCS1,ERRFI1,IDI1,PNRC1,CPEB2,HMGCR,ACTG1,TNFRSF12A,MAL2,TM7SF2,STX5
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_COAGULATION	HALLMARK_COAGULATION	0.100752636672621	0.369426334466276	0.391782940947837	1.32364817345592	32	up_in_group1	C1R,GSN,TIMP1,CFD,CRIP2,CD9,C1S,CLU
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_COMPLEMENT	HALLMARK_COMPLEMENT	0.256038647342995	0.609579504316347	0.276992689883588	1.11130828518601	63	up_in_group1	LTF,CTSC,C1R,TIMP1,CA2,PSMB9,C1S,CLU,PLSCR1,PFN1,S100A13
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_DNA_REPAIR	HALLMARK_DNA_REPAIR	0.0050722424049684	0.0318826665455156	0.372688734243153	1.60080245607784	85	up_in_group1	POLR2I,NME1,CETN2,PCNA,DUT,COX17,AK1,RPA3,GTF2F1,REV3L,DAD1,APRT,RBX1,POLR2J,ZWINT,XPC,NME3,EDF1,NELFE,VPS28,GTF2H5,SMAD5,POLR2F,SURF1,POLR2G,DGUOK,MRPL40,POLE4,SSRP1,POLR2K,BCAP31,MPG,POLR2H,UPF3B,RALA,SF3A3,TMED2,GPX4,NT5C,RNMT,IMPDH2,DDB1,NCBP2,HPRT1
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_E2F_TARGETS	HALLMARK_E2F_TARGETS	0.00130934528342056	0.0115222384941009	0.395005903399947	1.69666094579433	85	up_in_group1	PA2G4,RANBP1,NME1,NAA38,PCNA,DUT,CKS1B,HMGB2,HNRNPD,XRCC6,RPA3,SMC1A,STMN1,DNMT1,RFC1,CBX5,TUBB,ANP32E,PRKDC,RBBP7,MCM3,KIF22,DEK,EXOSC8,TMPO,PSIP1,AK2,NASP,PAICS,RAN,HMGB3,SMC3,NOP56,POLE4,SSRP1,CSE1L,SMC6,PTTG1,PNN,MCM4,BARD1,SMC4,STAG1,PRDX4,ILF3,RPA1,RAD50,MYC,DCTPP1
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	0.366935483870968	0.768817204301075	0.282659612306267	1.05251944930212	45	up_in_group1	DCN,TIMP1,VIM,PPIB,POSTN,FLNA,CD44,CALD1,CAPG,DST,TPM4,TPM1,SFRP1
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ESTROGEN_RESPONSE_EARLY	HALLMARK_ESTROGEN_RESPONSE_EARLY	0.186311787072243	0.546514575411914	-0.407775902850997	-1.23706378595974	61	up_in_group2	PPIF,HSPB8,AREG,SULT2B1,UGCG,PMAIP1,KLK10,ELF3,NRIP1,SLC19A2,WWC1,TIPARP,ZNF185,EGR3,SLC7A5,KLF10,ABLIM1,KLF4,ELOVL5,TOB1
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ESTROGEN_RESPONSE_LATE	HALLMARK_ESTROGEN_RESPONSE_LATE	0.634474327628362	0.845965770171149	-0.281237129088455	-0.884687806431576	75	up_in_group2	PPIF,HSPB8,AREG,S100A9,SULT2B1,KLK11,ISG20,ZFP36,ID2,KLK10
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_FATTY_ACID_METABOLISM	HALLMARK_FATTY_ACID_METABOLISM	0.289617486338798	0.637158469945355	0.261413938046376	1.07896293331478	73	up_in_group1	PSME1,CA2,MIF,ALDOA,MDH1,S100A10,HSD17B10,UBE2L6,LDHA,HIBCH,APEX1,LGALS1,ECHS1,OSTC,SDHC,BLVRA,GLUL,PRDX6,CBR1,SDHD,CBR3,DECR1,ECH1,ALDH9A1,IDH3B,PDHB,XIST,ECI1,IDH3G,YWHAH,PTS,GRHPR,UROD
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_G2M_CHECKPOINT	HALLMARK_G2M_CHECKPOINT	0.696969696969697	0.895450917797286	0.210150573559847	0.904236442267613	86	up_in_group1	SNRPD1,CENPF,CKS1B,HNRNPD,NCL,SMC1A,STMN1,HMGN2,DKC1,MCM3,KIF22,TMPO,NASP,MT2A,HMGB3,HNRNPU,EWSR1,FOXN3,PTTG1,BARD1,SQLE,SRSF10,SMC4,STAG1,MARCKS,DTYMK,SMC2,ILF3,ATRX,RAD23B,BUB3,MYC,G3BP1,SRSF1,CBX1
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_GLYCOLYSIS	HALLMARK_GLYCOLYSIS	0.244131455399061	0.609579504316347	0.283304877419237	1.12119354233955	61	up_in_group1	DCN,MIF,ENO1,ALDOA,CD44,MDH1,PPIA,STMN1,PKM,ANGPTL4,LDHA,FAM162A,UGP2,SDHC,NASP,TPBG,GPC1,PGK1,SOD1,TPI1
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HEME_METABOLISM	HALLMARK_HEME_METABOLISM	1	1	-0.143487297854731	-0.449993317794034	77	up_in_group2	MAP2K3,TOP1,ELL2,BNIP3L,YPEL5,RIOK3,FOXO3,ATP6V0A1,KAT2B,BACH1,ADIPOR1,MBOAT2,NEK7,NR3C1,BTRC,NCOA4,PICALM,MKRN1,GCLC,TSPAN5
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HYPOXIA	HALLMARK_HYPOXIA	0.121980676328502	0.412857673727239	-0.405385840541923	-1.29258759553188	84	up_in_group2	IER3,MAFF,PPP1R15A,SULT2B1,NEDD4L,CDKN1A,ATF3,IRS2,ISG20,ZFP36,TNFAIP3,ERRFI1,BNIP3L,DDIT3,RORA,ADM,CITED2,PNRC1,AMPD3,EFNA1,SDC4,JUN,FOSL2,TIPARP,KLHL24,FOXO3
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_IL2_STAT5_SIGNALING	HALLMARK_IL2_STAT5_SIGNALING	0.561097256857855	0.845965770171149	-0.303988055706812	-0.943334964209167	69	up_in_group2	GADD45B,MAFF,IL1RL1,HOPX,CD83,MXD1,PHLDA1,RORA,SNX9,PNP,RHOB,IL1R2,MAP3K8,SOCS1,POU2F1,GABARAPL1,PRNP,HUWE1,PRKCH
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_IL6_JAK_STAT3_SIGNALING	HALLMARK_IL6_JAK_STAT3_SIGNALING	0.148809523809524	0.467687074829932	0.394409793685906	1.25342318975402	24	up_in_group1	CD9,STAT1,CD44,IRF9,IFNGR1,SOCS3,LTBR
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INFLAMMATORY_RESPONSE	HALLMARK_INFLAMMATORY_RESPONSE	0.209698558322412	0.576671035386632	-0.417911847371354	-1.2220539345824	50	up_in_group2	CCL20,CXCL8,CDKN1A,NFKBIA,HBEGF,MXD1,EREG,CD55,ADM,KIF1B,SLC31A2,NAMPT,SGMS2,SELENOS
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INTERFERON_ALPHA_RESPONSE	HALLMARK_INTERFERON_ALPHA_RESPONSE	1.71315716723192e-07	3.76894576791023e-06	0.670152127667964	2.37317226136372	35	up_in_group1	IFITM1,IFITM3,PSME2,PSME1,PSMB9,CD47,C1S,PARP14,IFI30,PSMB8,LPAR6,IFI27,IRF9,PSMA3,NMI,PLSCR1,UBE2L6,NCOA7,LGALS3BP,HLA-C,TAP1,TXNIP
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INTERFERON_GAMMA_RESPONSE	HALLMARK_INTERFERON_GAMMA_RESPONSE	0.000630430688148479	0.00693473756963327	0.451133883149527	1.84513903212215	67	up_in_group1	CCL2,IFITM3,C1R,TNFSF10,PSME2,PSMB10,PSME1,RNF213,PSMB9,C1S,PARP14,MVP,IFI30,PSMB8,STAT1,TAPBP,IFI27,IRF9,PSMA3,NMI,PLSCR1,VAMP8,UBE2L6,PSMA2,LGALS3BP,TAP1
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_KRAS_SIGNALING_DN	HALLMARK_KRAS_SIGNALING_DN	0.502439024390244	0.835924006908463	-0.414396867282332	-0.980469130822347	16	up_in_group2	CALML5,SERPINB2,KLK7,SKIL
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_KRAS_SIGNALING_UP	HALLMARK_KRAS_SIGNALING_UP	0.0109195930969954	0.0600577620334747	-0.580024687828883	-1.63679991496307	40	up_in_group2	SLPI,CCL20,PPP1R15A,HBEGF,PRELID3B,PRDM1,ALDH1A3,TNFAIP3,ID2,EREG,GADD45G,TOR1AIP2
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MITOTIC_SPINDLE	HALLMARK_MITOTIC_SPINDLE	0.0906986214347571	0.362794485739028	0.304461768230369	1.26814106711756	75	up_in_group1	GSN,ARHGAP29,CENPF,FLNA,MYH9,CDC42EP1,SMC1A,DST,RFC1,SPTBN1,KIF22,PALLD,UXT,DYNC1H1,CAPZB,SMC3,ARF6,PCM1,ARHGDIA,CTTN,SMC4,MARCKS,NCK1,CDC42,ARHGAP5,YWHAE,RALBP1,FLNB,VCL
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MTORC1_SIGNALING	HALLMARK_MTORC1_SIGNALING	0.957762557077626	1	-0.19836222553748	-0.656952400653167	115	up_in_group2	PPP1R15A,MAP2K3,CDKN1A,SQSTM1,HMGCS1,DAPP1,IFRD1,UBE2D3,DDIT3,PNP,EDEM1,IDI1,TXNRD1,NFKBIB,NAMPT,ME1,INSIG1
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYC_TARGETS_V1	HALLMARK_MYC_TARGETS_V1	0.617391304347826	0.845965770171149	-0.273673187041935	-0.939185132805063	172	up_in_group2	RPS6,RPL18,RPL34,RPS2,RPS3,RPS5,RPL14,RPLP0,RPL6,RPL22,RPS10,RACK1
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYC_TARGETS_V2	HALLMARK_MYC_TARGETS_V2	0.00364694160589984	0.0267442384432655	0.57086604330466	1.81419616950742	24	up_in_group1	PA2G4,CBX3,MAP3K6,WDR43,DDX18,GNL3,HSPE1,NOP56,MPHOSPH10,MCM4,EXOSC5,IMP4,MRTO4,MYC,DCTPP1,NPM1,SRM,NOP16,CDK4,HSPD1
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYOGENESIS	HALLMARK_MYOGENESIS	0.512953367875648	0.835924006908463	-0.327254620164055	-0.962386909412242	52	up_in_group2	GADD45B,HSPB8,GABARAPL2,CDKN1A,HBEGF,IFRD1,SMTN,KIFC3
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_OXIDATIVE_PHOSPHORYLATION	HALLMARK_OXIDATIVE_PHOSPHORYLATION	1.04375194922762e-07	3.76894576791023e-06	0.437473111336612	2.07577454014824	152	up_in_group1	NDUFA3,NDUFB1,NDUFA1,UQCRQ,TIMM8B,UQCR11,COX7C,NDUFC1,NDUFB4,COX6A1,COX6B1,COX6C,NDUFB3,NDUFS6,UQCRB,NDUFB7,COX5B,NDUFA7,NDUFB8,NDUFC2,COX17,NDUFB2,CYB5R3,NDUFB6,NDUFA2,COX8A,MDH1,COX7A2,NDUFV2,MRPL34,MGST3,HSD17B10,NDUFA5,SLC25A5,NDUFA4,UQCR10,LDHA,NDUFAB1,UQCRC1,IDH2,ATP6V0C,ATP6V1F,COX4I1,TIMM13,NDUFS8,TIMM10,NDUFS7,ECHS1,AFG3L2,TOMM22,NDUFS3,COX5A,ETFB,VDAC1,SDHC,CYC1,UQCRH,VDAC3,POLR2F,LDHB,SURF1,SDHD,GPI,DECR1,MRPL15,NDUFV1,NDUFA8,CYCS,ISCU,COX7B,ECH1,NDUFB5,SDHB,NDUFS4,MRPS12,IDH3B,PDHB,NDUFA6,GPX4,ECI1,PRDX3,NDUFA9,MRPS22,COX7A2L,IDH3G
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_P53_PATHWAY	HALLMARK_P53_PATHWAY	0.0201514212309169	0.0985180593511492	-0.454017064255851	-1.48704337859835	103	up_in_group2	RPS12,RPL18,RPL36,GADD45A,IER3,KRT17,PPP1R15A,UPP1,RACK1,CDKN1A,ATF3,HBEGF,IER5,MXD1,HEXIM1,DDIT3,RPS27L,SLC19A2,PLK2,SLC3A2,TGFA,JUN,GM2A,EPHA2,SOCS1,FOXO3,PPM1D,TM4SF1,IP6K2
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PEROXISOME	HALLMARK_PEROXISOME	0.505494505494505	0.835924006908463	0.266646828594742	0.95110202596592	38	up_in_group1	CRABP2,MVP,TSPO,CTBP1,IDH2,PRDX5,GSTK1,SCP2
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PI3K_AKT_MTOR_SIGNALING	HALLMARK_PI3K_AKT_MTOR_SIGNALING	0.602053915275995	0.845965770171149	-0.302511136210567	-0.900702115797639	55	up_in_group2	MAP2K3,CDKN1A,SQSTM1,DAPP1,UBE2D3,DDIT3,NFKBIB,RPS6KA3,AKT1S1,EIF4E,MAPK8
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PROTEIN_SECRETION	HALLMARK_PROTEIN_SECRETION	0.962441314553991	1	0.179064844636896	0.715414269009809	62	up_in_group1	CTSC,ATP1A1,CD63,DST,ANP32E,COPB1,AP2S1,SOD1,RER1,TPD52,TMED2,COPE,AP3S1,RAB2A,AP2M1,TMED10,CAV2
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	0.605531295487627	0.845965770171149	-0.332542039496818	-0.885699657476084	28	up_in_group2	FTL,OXSR1,MGST1,TXNRD1,SELENOS,JUNB
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_SPERMATOGENESIS	HALLMARK_SPERMATOGENESIS	0.954828660436137	1	-0.220945935496863	-0.537568526258497	18	up_in_group2	SIRT1,BRAF,LPIN1,IP6K1
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_TGF_BETA_SIGNALING	HALLMARK_TGF_BETA_SIGNALING	0.455182072829132	0.834500466853408	-0.371428714253958	-1.01369589261801	32	up_in_group2	PPP1R15A,UBE2D3,ID2,SKIL,JUNB,TJP1,KLF10,PPM1A,TRIM33
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_TNFA_SIGNALING_VIA_NFKB	HALLMARK_TNFA_SIGNALING_VIA_NFKB	2.75388187733117e-07	4.03902675341905e-06	-0.625177958314356	-2.06919379521437	110	up_in_group2	CCL20,GADD45A,GADD45B,IER3,MAFF,PPP1R15A,AREG,MAP2K3,PHLDA2,CDKN1A,ATF3,NFKBIA,SQSTM1,EGR1,HBEGF,IER5,CD83,IRS2,SERPINB2,MXD1,EIF1,ZFP36,TNFAIP3,CCNL1,IER2,ID2,PER1,PHLDA1,DUSP5,FOSL1,PNRC1,NAMPT,RCAN1,EFNA1,SDC4,PLK2,JUN,JUNB,FOSL2,TIPARP,LITAF,RHOB,MAP3K8,CEBPB,SGK1,MCL1,ZC3H12A,NFAT5,EGR3,KLF10,KLF4,REL,GEM,NFKB1,BTG1,TSC22D1,SOD2,KDM6B,EHD1,TRIB1,SERPINB8
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	0.822002472187886	0.977516453412621	-0.239777949520711	-0.748155590271612	71	up_in_group2	RPS14,ATF4,ATF3,EIF4A1,EDEM1,ATP6V0D1,HERPUD1,DNAJA4,EIF4A2,EIF4E
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UV_RESPONSE_DN	HALLMARK_UV_RESPONSE_DN	0.950201884253028	1	-0.210461146369292	-0.604746811956673	44	up_in_group2	NR1D2,CITED2,INSIG1,ADGRL2,YTHDC1,TJP1,NIPBL,NFKB1,MGLL,FHL2,NEK7,NR3C1,DYRK1A
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UV_RESPONSE_UP	HALLMARK_UV_RESPONSE_UP	0.4214463840399	0.806245256424157	-0.332033578674022	-1.03036576001786	69	up_in_group2	PPIF,CTSV,ATF3,NFKBIA,SQSTM1,DNAJA1,SELENOW,CREG1,EIF5,NUP58,NXF1,MAOA,CDC34,JUNB,RHOB,DNAJB1
deg_findmarkers	AtopicDermatitis vs Control	keratinocytes	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_XENOBIOTIC_METABOLISM	HALLMARK_XENOBIOTIC_METABOLISM	0.982188295165394	1	-0.189204948595281	-0.569908289182653	59	up_in_group2	UPP1,SERTAD1,NDRG2,ID2,PPARD,MAOA,DDT,EPHA2,ACOX1,GABARAPL1
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ADIPOGENESIS	HALLMARK_ADIPOGENESIS	0.944162436548223	0.99492385786802	0.202661731187753	0.693988962857462	41	up_in_group1	DNAJC15,NMT1,G3BP2,PIM3,ETFB,UCP2,TANK,DHRS7,TOB1,COX6A1,ESYT1,COX8A,UQCRQ,NDUFB7,SCP2,COX7B
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ALLOGRAFT_REJECTION	HALLMARK_ALLOGRAFT_REJECTION	0.355875831485588	0.696570728720147	-0.429431029834503	-1.0990136666639	66	up_in_group2	RPS19,RPL39,RPS3A,RPL9,RPS9,CCL5,B2M,FYB1
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ANDROGEN_RESPONSE	HALLMARK_ANDROGEN_RESPONSE	0.392592592592593	0.696570728720147	0.359744569997693	1.06198953283132	26	up_in_group1	FKBP5,HPGD,ARID5B,SMS,PA2G4,TNFAIP8,MAF,XRCC5,IQGAP2,SPCS3,IDI1,XRCC6,INPP4B,TMEM50A,LMAN1,SRP19,GNAI3,DBI
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APICAL_JUNCTION	HALLMARK_APICAL_JUNCTION	0.70863309352518	0.869301832500379	0.295833532381774	0.849968707554388	24	up_in_group1	ITGB1,RSU1,YWHAH,RAC2,VASP,MSN,MYH9,PTPRC,ACTN4,CAP1,LIMA1
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_APOPTOSIS	HALLMARK_APOPTOSIS	0.353233830845771	0.696570728720147	0.320776748332586	1.08650407184787	40	up_in_group1	CLU,TNFSF10,TIMP1,BIRC3,LMNA,CD69,CD44,CASP8,CYLD,HMGB2,TAP1
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_COMPLEMENT	HALLMARK_COMPLEMENT	0.350253807106599	0.696570728720147	0.309046898162911	1.05829124755525	41	up_in_group1	CLU,GZMB,TIMP1,GNG2,CTSS,DOCK10,CTSC,ANXA5,HSPA5,GRB2,GATA3,ATOX1,USP15,RHOG
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_DNA_REPAIR	HALLMARK_DNA_REPAIR	0.99492385786802	0.99492385786802	0.132996632996633	0.455429818229271	41	up_in_group1	SUPT5H,COX17,XPC,NME1,HPRT1,RBX1,POLR2K,POLR2I,TMED2,SDCBP,RNMT,GTF2H5,POLR2G,ADRM1,MPC2,PDE4B,POLE4,DGUOK,BCAP31,RPA3,GUK1,HCLS1,NT5C,SUPT4H1,GTF2A2,DAD1,POLR1D,ARL6IP1,POLR3GL,POLR2E,EDF1,APRT,EIF1B,DUT,UPF3B,VPS28,POLR2J,NME3,GPX4,POLR2F,POLD4
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_E2F_TARGETS	HALLMARK_E2F_TARGETS	0.00150824069500133	0.0257144266126213	0.52392522911815	1.82768120386402	43	up_in_group1	RANBP1,TFRC,SYNCRIP,TRA2B,PA2G4,GSPT1,SMC4,ILF3,SMC3,RFC1,RAD21,SMC1A,NOP56,RAD50,DNMT1,EED,PRDX4,ANP32E,DEK,RAN,HMGB2,HNRNPD,RBBP7,NME1,SNRPB,PTTG1,NASP,XRCC6,TUBB
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	0.0574856410244034	0.223555270650458	0.513160642144002	1.43500684620686	20	up_in_group1	TPM4,CAPG,AREG,TIMP1,ITGB1,LGALS1,FLNA,CD44
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_ESTROGEN_RESPONSE_LATE	HALLMARK_ESTROGEN_RESPONSE_LATE	0.450704225352113	0.696570728720147	0.366884707780617	1.0516176013098	23	up_in_group1	BATF,CD9,AREG,FKBP5,ETFB,CD44,IL6ST,XBP1,TOB1,HPRT1
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_FATTY_ACID_METABOLISM	HALLMARK_FATTY_ACID_METABOLISM	0.452674897119342	0.696570728720147	0.331847583006096	0.998282153658264	28	up_in_group1	HPGD,SMS,LDHA,YWHAH,LGALS1,HSPH1,PSME1,GLUL,IDI1
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_G2M_CHECKPOINT	HALLMARK_G2M_CHECKPOINT	0.0147603935475321	0.0861022956939372	0.46830145749429	1.56490766508688	39	up_in_group1	MT2A,SYNCRIP,TRA2B,GSPT1,PAFAH1B1,SMC4,NCL,ILF3,RAD21,SMC1A,SNRPD1,SMARCC1,HNRNPU,FOXN3,HNRNPD,SFPQ,ATRX,HMGN2,KIF5B,PTTG1,EWSR1,NASP
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_GLYCOLYSIS	HALLMARK_GLYCOLYSIS	0.451219512195122	0.696570728720147	0.321221833240564	1.0040244009031	31	up_in_group1	PGK1,LDHA,PKM,ENO1,UGP2,PSMC4,HSPA5,CD44,ARPP19,TXN,NASP,PPIA,STMN1,GLRX,MIF,ZNF292,AKR1A1
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HEME_METABOLISM	HALLMARK_HEME_METABOLISM	0.457746478873239	0.696570728720147	0.364100974562453	1.04363846566449	23	up_in_group1	RNF19A,TFRC,TCEA1,CAST,UCP2,USP15,NR3C1,OPTN,BSG,PSMD9,SDCBP,TOP1,TNRC6B
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_HYPOXIA	HALLMARK_HYPOXIA	0.45273631840796	0.696570728720147	0.289475689104054	0.980484142156178	40	up_in_group1	ETS1,MT2A,PGK1,LDHA,ENO1,ANXA2,UGP2,HSPA5,GPI,MYH9
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_IL2_STAT5_SIGNALING	HALLMARK_IL2_STAT5_SIGNALING	0.000111966801335333	0.00391883804673665	0.561466675163881	1.98126244142631	44	up_in_group1	IL13,IL2RA,TNFRSF18,TNFSF10,CAPG,TNFRSF4,BATF,PHTF2,ADAM19,GLIPR2,HOPX,GPR65,AHR,CSF2
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_IL6_JAK_STAT3_SIGNALING	HALLMARK_IL6_JAK_STAT3_SIGNALING	0.0484173827481973	0.211826049523363	0.514168225191704	1.43692965227435	21	up_in_group1	IL2RA,CD9,IL2RG,CSF2,PTPN1,PTPN2,GRB2,IRF9,CD44,SOCS1,IL6ST,STAT1
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INFLAMMATORY_RESPONSE	HALLMARK_INFLAMMATORY_RESPONSE	0.651982378854626	0.869301832500379	0.268812740565905	0.861144584061618	34	up_in_group1	TNFSF10,TIMP1,NAMPT,AHR,ATP2B1,PTGER4,SLAMF1,CD69
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INTERFERON_ALPHA_RESPONSE	HALLMARK_INTERFERON_ALPHA_RESPONSE	0.674074074074074	0.869301832500379	0.292758296068156	0.864241664789846	26	up_in_group1	IFITM2,PARP14,PSME2,ELF1,IRF9,CASP8,IFITM1,TAP1,PSME1,SP110
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_INTERFERON_GAMMA_RESPONSE	HALLMARK_INTERFERON_GAMMA_RESPONSE	0.257142857142857	0.696570728720147	0.304183341216373	1.11658002251107	54	up_in_group1	TNFSF10,MT2A,RNF213,ARID5B,NAMPT,IFITM2,PARP14,RAPGEF6,PTPN1,MVP,PSME2,ITGB7,CD69,PTPN2,IRF9,SOCS1,CASP8,TAP1,PSMB2,STAT1,PSME1,SP110,STAT3
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_KRAS_SIGNALING_UP	HALLMARK_KRAS_SIGNALING_UP	0.0203704425503279	0.10185221275164	0.494614801370661	1.48792745353365	28	up_in_group1	ETS1,IL2RG,LY96,DOCK2,LCP1,BIRC3,CCSER2,CSF2,CTSS
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MITOTIC_SPINDLE	HALLMARK_MITOTIC_SPINDLE	0.00757091462179065	0.0662455029406682	0.497541210744805	1.62156569795811	35	up_in_group1	DOCK2,RASA2,PCM1,SOS1,PAFAH1B1,RAPGEF6,SMC4,SMC3,RFC1,SMC1A,EZR,CDC42,YWHAE,FLNA,MYH9,CAPZB,ACTN4,MAPRE1,KIF5B,ARF6,TLK1
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MTORC1_SIGNALING	HALLMARK_MTORC1_SIGNALING	0.00220409370965325	0.0257144266126213	0.461032533376253	1.73880849649921	58	up_in_group1	CD9,SLA,PGK1,TFRC,NAMPT,PRDX1,LDHA,CANX,EIF2S2,TCEA1,NMT1,CALR,ENO1,ACTR2,CTSC,ACTR3,PSMC4,PSMA4,HSPA5,CCT6A,PDAP1,GPI,ARPC5L,HSPD1,XBP1,SDF2L1,PSMC6,HPRT1,IDI1,CORO1A,UFM1,UBE2D3,PPIA,PSMA3,PSMD13,DDX39A,PPA1,GLRX
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYC_TARGETS_V1	HALLMARK_MYC_TARGETS_V1	0.0734229576008273	0.256980351602896	-0.48881358716816	-1.31017314883093	120	up_in_group2	RPL34,RPS3,RPS2,RPS6,RPL14,RPL18,RPL6,RPS10,RPS5,RPL22,RACK1,RPLP0
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_MYOGENESIS	HALLMARK_MYOGENESIS	0.209944751381215	0.668006027122049	0.455010701113592	1.21605221335441	16	up_in_group1	CLU,TPM3,ITGB1
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_OXIDATIVE_PHOSPHORYLATION	HALLMARK_OXIDATIVE_PHOSPHORYLATION	0.675847457627119	0.869301832500379	-0.339659337343424	-0.892379247876245	92	up_in_group2	ATP5F1E,ATP5MG,ATP5MC2,ATP5ME,SLC25A6,ATP5F1D,ATP5MF,ATP5MC3,ATP5PF,ATP5PD,ATP5PO
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_P53_PATHWAY	HALLMARK_P53_PATHWAY	0.011174436334802	0.0782210543436139	-0.653094357016283	-1.58582745903863	42	up_in_group2	RPS12,RPL36,RPL18,RACK1,RPS27L,BTG1,SAT1,STOM,CD81,PERP
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PEROXISOME	HALLMARK_PEROXISOME	0.516717325227964	0.75354609929078	0.363975583444537	0.990072930622613	18	up_in_group1	PRDX1,YWHAH,MVP,SMARCC1,ITGB1BP1
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PI3K_AKT_MTOR_SIGNALING	HALLMARK_PI3K_AKT_MTOR_SIGNALING	0.421245421245421	0.696570728720147	0.363126797067093	1.06099669202897	25	up_in_group1	IL2RG,SLA,CALR,ACTR2,ACTR3,GRB2,UBE2N
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_PROTEIN_SECRETION	HALLMARK_PROTEIN_SECRETION	0.729452054794521	0.869301832500379	0.301183705348446	0.841708561114765	21	up_in_group1	CTSC,ANP32E,CD63,COPE,LMAN1,COPB1,RER1,TMED2,GOLGA4,VPS4B,AP3S1,TMED10
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	0.951367781155015	0.99492385786802	0.222504315304837	0.60524801538949	18	up_in_group1	PRDX1,MBP,PRDX4,LAMTOR5,ATOX1,TXN,NDUFB4,NDUFA6,PRNP,GLRX
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_TNFA_SIGNALING_VIA_NFKB	HALLMARK_TNFA_SIGNALING_VIA_NFKB	0.769953051643192	0.869301832500379	-0.313902433159065	-0.78460731671132	52	up_in_group2	CCL5,BTG1,SAT1,JUNB,IER2,IL7R,NR4A2,TNF,EIF1,PNRC1,FOSB,LITAF,SQSTM1,DUSP1,MCL1,CEBPB,ZFP36
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	0.757536041939712	0.869301832500379	-0.332889784634067	-0.772092719080751	32	up_in_group2	RPS14
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group1	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UV_RESPONSE_DN	HALLMARK_UV_RESPONSE_DN	0.425531914893617	0.696570728720147	0.390376804470731	1.06188855634687	18	up_in_group1	RASA2,ANXA2,ATP2B1,MRPS31,PHF3,PRDM2,ATRX,NR3C1,INPP4B
deg_findmarkers	AtopicDermatitis vs Control	tcell	up_in_group2	ad	control	fgsea::fgsea	MSigDB	signed_log2fc	HALLMARK_UV_RESPONSE_UP	HALLMARK_UV_RESPONSE_UP	0.994871794871795	0.99492385786802	-0.179994418060046	-0.42455659264105	36	up_in_group2	BTG1,SELENOW,JUNB,FOSB,AQP3,SQSTM1